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J. Neur. Syst."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p> Cognitive flexibility refers to the capacity to shift between patterns of mental function and relies on functional activity supported by anatomical structures. However, how the brain\u2019s structural\u2013functional covarying is preconfigured in the resting state to facilitate cognitive flexibility under tasks remains unrevealed. Herein, we investigated the potential relationship between individual cognitive flexibility performance during the trail-making test (TMT) and structural\u2013functional covariation of the large-scale multimodal covariance network (MCN) using magnetic resonance imaging (MRI) and electroencephalograph (EEG) datasets of 182 healthy participants. Results show that cognitive flexibility correlated significantly with the intra-subnetwork covariation of the visual network (VN) and somatomotor network (SMN) of MCN. Meanwhile, inter-subnetwork interactions across SMN and VN\/default mode network\/frontoparietal network (FPN), as well as across VN and ventral attention network (VAN)\/dorsal attention network (DAN) were also found to be closely related to individual cognitive flexibility. After using resting-state MCN connectivity as representative features to train a multi-layer perceptron prediction model, we achieved a reliable prediction of individual cognitive flexibility performance. Collectively, this work offers new perspectives on the structural\u2013functional coordination of cognitive flexibility and also provides neurobiological markers to predict individual cognitive flexibility. <\/jats:p>","DOI":"10.1142\/s0129065724500187","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T05:06:56Z","timestamp":1705727216000},"source":"Crossref","is-referenced-by-count":13,"title":["Multimodal Covariance Network Reflects Individual Cognitive Flexibility"],"prefix":"10.1142","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7892-118X","authenticated-orcid":false,"given":"Lin","family":"Jiang","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 610054, P.\u00a0R.\u00a0China"},{"name":"School of Life Science and Technology, Center for Information in Medicine, University of 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