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J. Neur. Syst."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>The behavioral inhibition system (BIS), mediating responses to punishment cues and avoidance behaviors, is implicated in anxiety. However, the neural dynamics underpinning BIS, particularly regarding the temporal variability of brain network interactions, remain less explored. Using resting-state functional magnetic resonance imaging (rs-fMRI) of 181 healthy adults, this study investigated the association between BIS sensitivity and the temporal variability of functional connectivity within and between functional brain networks. This finding revealed a significant positive correlation between BIS scores and temporal variability, specifically in the connectivity involving subnetworks\u2019 sensory somatomotor hand network (SSHN)-ventral attention network (VAN), and sensory somatomotor mouth network (SSMN)-VAN. Notably, the high-BIS sensitivity group exhibited significantly greater temporal variability between VAN and SSMN\/SSHN compared to the low-BIS sensitivity group. Furthermore, predicted BIS scores based on network variability showed a strong correlation with actual BIS scores (Pearson\u2019s [Formula: see text]). Moreover, significant mediation effects highlighted the bridging role of BIS scores between brain network variability and anxiety scale scores. This enhances the comprehension of the relationship between BIS, anxiety, and brain function, while also offering new insights into the pathogenesis of anxiety.<\/jats:p>","DOI":"10.1142\/s0129065725500558","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T06:47:12Z","timestamp":1753426032000},"source":"Crossref","is-referenced-by-count":1,"title":["Brain Connectivity Variability Influences Anxiety Through the Behavioral Inhibition System"],"prefix":"10.1142","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0378-8995","authenticated-orcid":false,"given":"Runyang","family":"He","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu 611731, 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