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The simulation results show how two people who are high in personality traits such as agreeableness, openness, extraversion, conscientiousness, and highly sensitive to neuroticism, are vulnerable to reaching a burnout level in all dimensions whenever the organizational context is changing in a less favorable direction. By a What-If analysis, it is analyzed how important characteristics affect the outcomes and indicate how, in a qualitative sense, that is in line with empirical literature. Several differentiations are made. In particular, the connection between the three dimensions of burnout shows that it is possible that one employee reaches a burnout state while the other does not. It is also shown how therapy alone may not be sufficient as a long-term treatment, but therapy of one employee does affect the other. 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