{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T04:06:12Z","timestamp":1648872372544},"reference-count":0,"publisher":"World Scientific Pub Co Pte Lt","issue":"supp01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neur. Syst."],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p> The standard theory of a leaky integrator with stochastic spike input predicts that cortical cells should fire regularly. We tested interspike-interval histograms from awake, behaving macaque visual cortex (V1 and MT), and found high levels of variability (CV&gt;0.5) characteristic of a nearly random (Poisson) process. A simple integrate-and-fire model, using accepted biophysical parameters, fails by more than a factor of ten to account for the high CV. We also simulated a biophysically detailed compartment-model of an anatomically reconstructed and physiologically characterized layer V pyramidal cell; again, at high firing rate, CV values are low, in disagreement with the data. Only a few situations could account for this discrepency: very large EPSP\u2019s, a very short membrane time constant (\u03c4m&lt;0.3 msec), highly synchronized input, or spikes in excitable dendrites. Our analysis suggests that cortical computation may occur at a time-scale much faster than previously realized. <\/jats:p>","DOI":"10.1142\/s0129065792000498","type":"journal-article","created":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T03:29:42Z","timestamp":1101266982000},"page":"169-173","source":"Crossref","is-referenced-by-count":0,"title":["Cortical Cells Do NOT Perform Temporal Integration of Small EPSPs"],"prefix":"10.1142","volume":"03","author":[{"given":"William","family":"Softky","sequence":"first","affiliation":[{"name":"Computation and Neural Systems Program, 216\u201376 Caltech, Pasadena, CA 91125, USA"}]},{"given":"Christof","family":"Koch","sequence":"additional","affiliation":[{"name":"Computation and Neural Systems Program, 216\u201376 Caltech, Pasadena, CA 91125, USA"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"container-title":["International Journal of Neural Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0129065792000498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T16:22:20Z","timestamp":1565194940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0129065792000498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":0,"journal-issue":{"issue":"supp01","published-online":{"date-parts":[[2011,11,21]]},"published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1142\/S0129065792000498"],"URL":"https:\/\/doi.org\/10.1142\/s0129065792000498","relation":{},"ISSN":["0129-0657","1793-6462"],"issn-type":[{"value":"0129-0657","type":"print"},{"value":"1793-6462","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}