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We profile the sensitivity of the elements and covalent bonds in a chemical structure network algorithmically, asking whether reprogrammability affords information about thermodynamic and chemical processes involved in the transformation of different compound classes. We arrive at numerical results suggesting a correspondence between some physical, structural and functional properties. Our methods are capable of separating chemical classes that reflect functional and natural differences without considering any information about atomic and molecular properties. We conclude that these methods, with their links to chemoinformatics via algorithmic, probability hold promise for future research.<\/jats:p>","DOI":"10.1142\/s0129626418500056","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T01:56:24Z","timestamp":1522634184000},"page":"1850005","source":"Crossref","is-referenced-by-count":8,"title":["Algorithmic Complexity and Reprogrammability of Chemical Structure Networks"],"prefix":"10.1142","volume":"28","author":[{"given":"Hector","family":"Zenil","sequence":"first","affiliation":[{"name":"Algorithmic Dynamics Lab, Centre for Molecular Medicine, Karolinska Institute, Stockholm, Sweden"},{"name":"Unit of Computational Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden"},{"name":"Science for Life Laboratory, SciLifeLab, Stockholm, Sweden"},{"name":"Algorithmic Nature Group, LABORES for the Natural and Digital Sciences, Paris, France"}]},{"given":"Narsis A.","family":"Kiani","sequence":"additional","affiliation":[{"name":"Algorithmic Dynamics Lab, Centre for Molecular Medicine, Karolinska Institute, Stockholm, Sweden"},{"name":"Unit of Computational Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden"},{"name":"Science for Life Laboratory, SciLifeLab, Stockholm, Sweden"},{"name":"Algorithmic Nature Group, LABORES for the Natural and Digital Sciences, Paris, France"}]},{"given":"Ming-mei","family":"Shang","sequence":"additional","affiliation":[{"name":"Unit of Computational Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden"},{"name":"Science for Life Laboratory, SciLifeLab, Stockholm, Sweden"}]},{"given":"Jesper","family":"Tegn\u00e9r","sequence":"additional","affiliation":[{"name":"Unit of Computational Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden"},{"name":"Science for Life Laboratory, SciLifeLab, Stockholm, Sweden"},{"name":"Biological and Environmental Sciences and Engineering, Division Computer, Electrical and Mathematical Sciences and, Engineering Division, King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia"}]}],"member":"219","published-online":{"date-parts":[[2018,4]]},"reference":[{"key":"S0129626418500056BIB001","doi-asserted-by":"publisher","DOI":"10.1080\/09537100400009321"},{"key":"S0129626418500056BIB002","doi-asserted-by":"publisher","DOI":"10.1103\/RevModPhys.74.47"},{"key":"S0129626418500056BIB003","doi-asserted-by":"publisher","DOI":"10.1016\/j.physrep.2014.07.001"},{"key":"S0129626418500056BIB004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ins.2010.08.041"},{"key":"S0129626418500056BIB005","doi-asserted-by":"publisher","DOI":"10.1021\/ja00402a071"},{"key":"S0129626418500056BIB006","doi-asserted-by":"publisher","DOI":"10.1145\/321356.321363"},{"key":"S0129626418500056BIB007","doi-asserted-by":"publisher","DOI":"10.1016\/j.amc.2014.05.105"},{"key":"S0129626418500056BIB008","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.01.016"},{"key":"S0129626418500056BIB009","doi-asserted-by":"publisher","DOI":"10.1016\/j.amc.2011.10.006"},{"issue":"2","key":"S0129626418500056BIB010","volume":"27","author":"Hendrickson J. 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