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As the former implemented models are not in place to segment the abnormal region properly, it suggests developing an effective automated model using recently emerged techniques of deep learning. To surmount such challenging factors, a novel 3D brain tumor segmentation model is proposed with hybrid heuristic development. Initially, the brain images are collected from the standard benchmark datasets. The collected brain images are pre-processed using the adaptive technique of Contrast Limited Adaptive Histogram Equalization (CLAHE). The pre-processed images are segmented with the developed Multiscale Self-Guided Attention Mechanism-based Adaptive UNet3[Formula: see text] (MSGAM-AUNet3[Formula: see text]), where the parameters are optimized with the hybrid optimization strategy of Modified Path Finder Coyote Optimization (MPFCO) to elevate the segmentation performance. The experimental analysis is carried out to estimate the efficiency of the developed framework with the comparison using diverse segmentation techniques. <\/jats:p>","DOI":"10.1142\/s0218001424510017","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T15:23:37Z","timestamp":1709997817000},"source":"Crossref","is-referenced-by-count":3,"title":["Design of Novel Brain Tumor Segmentation System Using Hybrid Heuristic-Aided Multiscale Self-Guided Attention Mechanism-Based Adaptive Unet+++ with 3D Brain MRI Images"],"prefix":"10.1142","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9611-8008","authenticated-orcid":false,"given":"D.","family":"Ramya","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Tamil Nadu 603 203, 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