{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T22:10:05Z","timestamp":1648851005804},"reference-count":15,"publisher":"World Scientific Pub Co Pte Lt","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J CIRCUIT SYST COMP"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p> Many human tumors cannot easily be avoided. In most cases a prophylactic vaccination prevents the tumor growth. In particular the Triplex vaccine prevented mammary carcinoma formation using a Chronic schedule, but it is not known if this schedule is minimal. A computational model named SimTriplex was able to reproduce in silico the in vivo experiments. The combination of SimTriplex and Genetic Algorithms (GA), produced a minimal vaccination schedule capable to guarantee in silico survival. This process required the use of a High Performance Computing (HPC) infrastructure for several days. In this paper we show another optimization procedure based on simulated annealing approach used to get a faster algorithm response. <\/jats:p>","DOI":"10.1142\/s0218126609005770","type":"journal-article","created":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T04:34:31Z","timestamp":1259555671000},"page":"1565-1579","source":"Crossref","is-referenced-by-count":3,"title":["SIMULATED ANNEALING AND OPTIMAL PROTOCOLS"],"prefix":"10.1142","volume":"18","author":[{"given":"MARZIO","family":"PENNISI","sequence":"first","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Catania, Catania, Italy"}]},{"given":"ROBERTO","family":"CATANUTO","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Catania, Catania, Italy"}]},{"given":"FRANCESCO","family":"PAPPALARDO","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Catania, Catania, Italy"}]},{"given":"SANTO","family":"MOTTA","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Catania, Catania, Italy"}]},{"given":"EMILIO","family":"MASTRIANI","sequence":"additional","affiliation":[{"name":"COMETA, COnsorzio Multi Ente per la promozione e l'adozione di, Tecnologie di calcolo Avanzato, Catania, Italy"}]},{"given":"ALESSANDRO","family":"CINCOTTI","sequence":"additional","affiliation":[{"name":"School of Information Science, Japan Advanced Institute of Science and Technology, Japan"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1699114"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1126\/science.220.4598.671"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-7744-1"},{"key":"rf4","volume-title":"Mathematical Control Theory: An Introduction","author":"Zabczyk J.","year":"1993"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1002\/9781118033142"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-6095-8"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.9.1195"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2984"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1517\/14796694.1.1.57"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti426"},{"key":"rf11","volume":"7","author":"Lollini P.","journal-title":"BMC Bioinformatics"},{"key":"rf12","author":"Pennisi M.","journal-title":"IEEE Engineering in Medicine and Biology Magazine"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm408"},{"key":"rf15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn306"},{"key":"rf16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2007.03.002"}],"container-title":["Journal of Circuits, Systems and Computers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0218126609005770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T14:08:18Z","timestamp":1565186898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0218126609005770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":15,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2011,11,21]]},"published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1142\/S0218126609005770"],"URL":"https:\/\/doi.org\/10.1142\/s0218126609005770","relation":{},"ISSN":["0218-1266","1793-6454"],"issn-type":[{"value":"0218-1266","type":"print"},{"value":"1793-6454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}