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In this context, No-Instruction-Set-Computer (NISC) concept have been introduced considering that a dedicated processor to a specific application does not need an instruction set especially when it is programmed by its designers and not by its users. In this paper, the hardware architecture design of flexible NISC-based architecture design dedicated for minimum mean-squared error (MMSE) linear detection is presented. The devised design, which is used in iterative turbo-receiver, fulfills the performance requirements of emergent wireless communication standards with throughput reaching that of LTE-Advanced. FPGA hardware implementation of the detector architecture achieves a maximum throughput of 115.8 Mega symbols per second for [Formula: see text] and 6.4 Mega symbols per second for [Formula: see text] MIMO systems for an operating clock frequency of 202.67[Formula: see text]MHz. <\/jats:p>","DOI":"10.1142\/s0218126621500699","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T15:03:26Z","timestamp":1593529406000},"page":"2150069","source":"Crossref","is-referenced-by-count":1,"title":["NISC-Based MIMO MMSE Detector"],"prefix":"10.1142","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-7534","authenticated-orcid":false,"given":"Mostafa","family":"Rizk","sequence":"first","affiliation":[{"name":"CCE Department, International University of Beirut, Beirut, Lebanon"},{"name":"Physics and Electronics Department, Faculty of Sciences, Lebanese University, Hadat, Lebanon"},{"name":"Electronics Department, IMT Atlantique, CNRS Lab-STICC, UBL, F-29238 Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer","family":"Baghdadi","sequence":"additional","affiliation":[{"name":"Electronics Department, IMT Atlantique, CNRS Lab-STICC, UBL, F-29238 Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"J\u00e9z\u00e9quel","sequence":"additional","affiliation":[{"name":"Electronics Department, IMT Atlantique, CNRS Lab-STICC, UBL, F-29238 Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef","family":"Atat","sequence":"additional","affiliation":[{"name":"Computer Sciences Department, Faculty of Sciences, Lebanese University, Hadat, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser","family":"Mohanna","sequence":"additional","affiliation":[{"name":"Physics and Electronics Department, Faculty of Sciences, Lebanese University, Hadat, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"S0218126621500699BIB001","doi-asserted-by":"publisher","DOI":"10.1109\/ICC.1993.397441"},{"key":"S0218126621500699BIB002","doi-asserted-by":"publisher","DOI":"10.1002\/ett.4460060506"},{"key":"S0218126621500699BIB003","doi-asserted-by":"publisher","DOI":"10.1109\/GLOCOM.1998.775793"},{"key":"S0218126621500699BIB004","doi-asserted-by":"publisher","DOI":"10.1109\/TWC.2005.847095"},{"key":"S0218126621500699BIB005","doi-asserted-by":"publisher","DOI":"10.1007\/978-2-8178-0039-4"},{"key":"S0218126621500699BIB007","first-page":"175","volume-title":"Proc. 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