{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:40:23Z","timestamp":1767854423151,"version":"3.49.0"},"reference-count":48,"publisher":"World Scientific Pub Co Pte Lt","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Bifurcation Chaos"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p> In this work, the authors use computer modeling to theoretically investigate the mechanisms involved in figure-of-eight reentry during acute regional myocardial ischemia, a pattern of excitation which may lead to ventricular fibrillation and sudden cardiac death. For this purpose, a modified version of the Luo\u2013Rudy dynamic model for the action potential and ionic currents has been used, together with a two-dimensional model of the regionally ischemic ventricle. The virtual tissue comprises several realistically dimensioned and located transitional border zones for hyperkalemia, hypoxia and acidosis, simulating the substrate heterogeneity created by acute ischemia. Different types of patterns of excitation following the delivery of a premature stimulus were obtained, including figure-of-eight reentry. Action potentials and selected ionic currents which explain the reentry process are analyzed. The effect of the degree of ATP-sensitive current activation in the vulnerability to reentry is also studied. The results are in accordance with experimental observations, and demonstrate the ability of second-generation mathematical models to analyze and explain the mechanisms involved in ischemic reentry. <\/jats:p>","DOI":"10.1142\/s0218127403008806","type":"journal-article","created":{"date-parts":[[2004,1,29]],"date-time":"2004-01-29T09:19:29Z","timestamp":1075367969000},"page":"3703-3715","source":"Crossref","is-referenced-by-count":44,"title":["ELECTRICAL ACTIVITY AND REENTRY DURING ACUTE  REGIONAL MYOCARDIAL ISCHEMIA: INSIGHTS FROM SIMULATIONS"],"prefix":"10.1142","volume":"13","author":[{"suffix":"JR","given":"JOS\u00c9 M.","family":"FERRERO","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s\/n, 46020 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BEATRIZ","family":"TR\u00c9NOR","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s\/n, 46020 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BLANCA","family":"RODR\u00cdGUEZ","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s\/n, 46020 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAVIER","family":"S\u00c1IZ","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s\/n, 46020 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2011,11,20]]},"reference":[{"key":"rf1","first-page":"8","volume":"41","author":"Allessie M.","journal-title":"Circ. Res."},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.65.2.436"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00731.2001"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1142\/S0218127499000481"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00726.x"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1109\/10.900247"},{"key":"rf7","volume-title":"Distribution of Extracellular Potassium During Myocardial Ischemia","author":"Coronel R.","year":"1988"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.5.1125"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.6.770"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3721"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.3.455"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0779(95)95761-F"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.2.208"},{"key":"rf14","first-page":"487","volume":"26","author":"Ferrero J. M.","journal-title":"Comput. Cardiol."},{"key":"rf15","first-page":"239","volume":"27","author":"Ferrero J. M.","journal-title":"Comput. Cardiol."},{"key":"rf16","first-page":"540","volume":"261","author":"Findlay I.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"rf17","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.57.3.432"},{"key":"rf18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.9.2454"},{"key":"rf19","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.59.3.348"},{"key":"rf20","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.44.4.576"},{"key":"rf21","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.47.2.151"},{"key":"rf22","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.49.5.1069"},{"key":"rf23","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.42.5.603"},{"key":"rf24","doi-asserted-by":"publisher","DOI":"10.1007\/BF01956039"},{"key":"rf25","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(84)80591-X"},{"key":"rf26","doi-asserted-by":"publisher","DOI":"10.1007\/BF02368286"},{"key":"rf27","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.6.1071"},{"key":"rf28","first-page":"43","volume":"8","author":"Mines G. R.","journal-title":"Trans. R. Soc. Can. Ser."},{"key":"rf29","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(64)90371-0"},{"key":"rf30","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.46.5.634"},{"key":"rf31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702704"},{"key":"rf32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00625.2001"},{"key":"rf33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1995.tb00402.x"},{"key":"rf34","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.1.124"},{"key":"rf35","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00093-X"},{"key":"rf36","doi-asserted-by":"publisher","DOI":"10.1007\/BF02347695"},{"key":"rf37","doi-asserted-by":"publisher","DOI":"10.1142\/S0218127401003590"},{"key":"rf38","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.3.595"},{"key":"rf39","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-3291-6_20"},{"key":"rf40","doi-asserted-by":"crossref","first-page":"H982","DOI":"10.1152\/ajpheart.1986.250.6.H982","volume":"250","author":"Weiss J. N.","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"rf41","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019022"},{"key":"rf42","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(89)80200-0"},{"key":"rf43","volume-title":"The Ventricular Arrhythmias of Ischemia and Infarction: Electrophysiological Mechanisms","author":"Wit A. L.","year":"1993"},{"key":"rf44","doi-asserted-by":"crossref","first-page":"H1667","DOI":"10.1152\/ajpheart.2001.280.4.H1667","volume":"280","author":"Xie F.","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"rf45","doi-asserted-by":"publisher","DOI":"10.1063\/1.166286"},{"key":"rf46","doi-asserted-by":"publisher","DOI":"10.1007\/BF01869203"},{"key":"rf47","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.1.140"},{"key":"rf48","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.21.2334"}],"container-title":["International Journal of Bifurcation and Chaos"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0218127403008806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T15:12:24Z","timestamp":1565190744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0218127403008806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,11,20]]},"published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1142\/S0218127403008806"],"URL":"https:\/\/doi.org\/10.1142\/s0218127403008806","relation":{},"ISSN":["0218-1274","1793-6551"],"issn-type":[{"value":"0218-1274","type":"print"},{"value":"1793-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}