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The effect of behavior therapy is explained by the time-variant input stimulus weakening neural interconnections according to the covariance rule concerning synaptic plasticity. The effect of neurosurgical treatment is explained by the lesions to the cortical-striatal-thalamic-cortical loop decreasing the feedback of the closed loop. These treatments have a common property that they decrease the stability of stored information in the striatum. <\/jats:p>","DOI":"10.1142\/s0218127404009156","type":"journal-article","created":{"date-parts":[[2004,3,12]],"date-time":"2004-03-12T08:57:28Z","timestamp":1079081848000},"page":"263-277","source":"Crossref","is-referenced-by-count":4,"title":["COMPUTATIONAL MODEL OF OBSESSIVE\u2013COMPULSIVE DISORDER: A UNIFIED EXPLANATION OF THE TREATMENTS"],"prefix":"10.1142","volume":"14","author":[{"given":"SHIGERU","family":"KUBOTA","sequence":"first","affiliation":[{"name":"Graduate School of Frontier Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUYUKI","family":"AIHARA","sequence":"additional","affiliation":[{"name":"Graduate School of Frontier Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan"},{"name":"ERATO, JST, 4-1-8 Hon-cho, Kawaguchi, Saitama 332-0012, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2011,11,20]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-6080(96)00061-5"},{"key":"rf2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0375-9601(90)90136-C","volume":"144","author":"Aihara K.","journal-title":"Phys. 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