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To select an appropriate model we performed parameter estimation by maximum likelihood and statistical testing. We apply this approach to the JAK-STAT signalling pathway that was believed to represent a feed-forward cascade. We show by comparison of different models that this hypothesis is insufficient to explain the experimental data and suggest a new model including a delayed feedback. <\/jats:p>","DOI":"10.1142\/s0218127404010461","type":"journal-article","created":{"date-parts":[[2004,7,9]],"date-time":"2004-07-09T12:53:32Z","timestamp":1089377612000},"page":"2069-2079","source":"Crossref","is-referenced-by-count":54,"title":["MODELING THE NONLINEAR DYNAMICS OF CELLULAR SIGNAL TRANSDUCTION"],"prefix":"10.1142","volume":"14","author":[{"given":"J.","family":"TIMMER","sequence":"first","affiliation":[{"name":"Freiburger Zentrum f\u00fcr Datenanalyse  und Modellbildung, Eckerstr. 1, 79104 Freiburg, Germany"},{"name":"Fakult\u00e4t f\u00fcr Physik,  Hermann \u2013 Herder Str. 3, 79104 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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