{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:52:12Z","timestamp":1776322332934,"version":"3.50.1"},"reference-count":35,"publisher":"World Scientific Pub Co Pte Lt","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Bifurcation Chaos"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p> Inferior olive (IO) neurons project to the cerebellum and contribute to motor control. They can show intriguing spatio-temporal dynamics with rhythmic and synchronized spiking. IO neurons are connected to their neighbors via gap junctions to form an electrically coupled network, and so it is considered that this coupling contributes to the characteristic dynamics of this nucleus. Here, we demonstrate that a gap junction-coupled network composed of simple conductance-based model neurons (a simplified version of a Hodgkin\u2013Huxley type neuron) reproduce important aspects of IO activity. The simplified phenomenological model neuron facilitated the analysis of the single cell and network properties of the IO while still quantitatively reproducing the spiking patterns of complex spike activity observed by simultaneous recording in anesthetized rats. The results imply that both intrinsic bistability of each neuron and gap junction coupling among neurons play key roles in the generation of the spatio-temporal dynamics of IO neurons. <\/jats:p>","DOI":"10.1142\/s0218127410025909","type":"journal-article","created":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T08:50:35Z","timestamp":1270111835000},"page":"583-603","source":"Crossref","is-referenced-by-count":16,"title":["QUANTITATIVE MODELING OF SPATIO-TEMPORAL DYNAMICS OF INFERIOR OLIVE NEURONS WITH A SIMPLE CONDUCTANCE-BASED MODEL"],"prefix":"10.1142","volume":"20","author":[{"given":"YUICHI","family":"KATORI","sequence":"first","affiliation":[{"name":"Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERIC J.","family":"LANG","sequence":"additional","affiliation":[{"name":"Department of Physiology &amp; Neuroscience, New York University, School of Medicine, 550 First Avenue, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIHO","family":"ONIZUKA","sequence":"additional","affiliation":[{"name":"Graduate School of Information Science, Nara Institute of Science and Technology, Nara 630-9192, Japan"},{"name":"ATR Computational Neuroscience Labs, Department of Communiation and Cognitive Cybernetics, Hikaridai 2-2-2, Keihanna Science City, Kyoto 619-0288, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MITSUO","family":"KAWATO","sequence":"additional","affiliation":[{"name":"ATR Computational Neuroscience Labs, Hikaridai 2-2-2, Keihanna Science City Kyoto 619-0288, Japan"},{"name":"Graduate School of Information Science, Nara Institute of Science and Technology, Nara 630-9192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUYUKI","family":"AIHARA","sequence":"additional","affiliation":[{"name":"Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,5,2]]},"reference":[{"key":"rf1","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1152\/jn.1997.77.6.3145","volume":"77","author":"Bal T.","journal-title":"J. Neurophysiol."},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02300-3"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(86)90089-4"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(92)90006-I"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3677-05.2006"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00163.x"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902840103"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1966.sp007824"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1952.sp004764"},{"key":"rf10","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/2526.001.0001","volume-title":"Dynamical Systems in Neuroscience: The Geometry of Excitability and Bursting","author":"Izhikevich E. M.","year":"2006"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00201431"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00588-X"},{"key":"rf13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1152\/jn.1996.76.1.255","volume":"76","author":"Lang E. J.","journal-title":"J. Neurophysiol."},{"key":"rf14","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1523\/JNEUROSCI.19-07-02728.1999","volume":"19","author":"Lang E. J.","journal-title":"J. Neurosci."},{"key":"rf15","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1523\/JNEUROSCI.21-05-01663.2001","volume":"21","author":"Lang E. J.","journal-title":"J. Neurosci."},{"key":"rf16","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1152\/jn.00477.2001","volume":"87","author":"Lang E. J.","journal-title":"J. Neurophysiol."},{"key":"rf17","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00353.2005"},{"key":"rf18","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1152\/jn.1974.37.3.560","volume":"37","author":"Llinas R.","journal-title":"J. Neurophysiol."},{"key":"rf19","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013763"},{"key":"rf20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013764"},{"key":"rf21","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016147"},{"key":"rf22","doi-asserted-by":"publisher","DOI":"10.1038\/nn1393"},{"key":"rf23","doi-asserted-by":"crossref","first-page":"10898","DOI":"10.1523\/JNEUROSCI.22-24-10898.2002","volume":"22","author":"Long M. A.","journal-title":"J. Neurosci."},{"key":"rf24","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1152\/jn.1997.77.5.2736","volume":"77","author":"Manor Y.","journal-title":"J. Neurophysiol."},{"key":"rf25","doi-asserted-by":"publisher","DOI":"10.1080\/14734220601100801"},{"key":"rf26","doi-asserted-by":"publisher","DOI":"10.1093\/comjnl\/7.4.308"},{"key":"rf27","first-page":"86","volume":"17","author":"Nelson B.","journal-title":"The Olivocerebellar System in Motor Control"},{"key":"rf28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0146-06.2006"},{"key":"rf29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1989.tb00364.x"},{"key":"rf30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00007.x"},{"key":"rf31","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1152\/jn.1999.82.2.804","volume":"82","author":"Schweighofer N.","journal-title":"J. Neurophysiol."},{"key":"rf32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biosystems.2004.09.023"},{"key":"rf33","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902520103"},{"key":"rf34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.03.016"},{"key":"rf35","doi-asserted-by":"publisher","DOI":"10.1038\/374453a0"}],"container-title":["International Journal of Bifurcation and Chaos"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0218127410025909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T12:48:08Z","timestamp":1565182088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0218127410025909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":35,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2012,5,2]]},"published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1142\/S0218127410025909"],"URL":"https:\/\/doi.org\/10.1142\/s0218127410025909","relation":{},"ISSN":["0218-1274","1793-6551"],"issn-type":[{"value":"0218-1274","type":"print"},{"value":"1793-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}