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The reason is that we do not have realistic network models of the heart system. Recently, Yazawa clarified the network structure of the heart and the central nerve system in the crustacean heart. In this study, we construct a simple model of the heart system based on Yazawa\u2019s experimental data. Using this model, we clarify that two parameters (the conductance of sodium ions and free concentration of potassium ions in the extracellular compartment) play the key roles of generating alternans. In particular, we clarify that the inactivation gate of the time-independent potassium channel is the most important parameter. Moreover, interaction between the membrane potential and potassium ionic currents is significant for generating alternate rhythms. This result indicates that if the muscle cell has problems such as channelopathies, there is great risk of generating alternans. <\/jats:p>","DOI":"10.1142\/s0218127416500759","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T02:25:31Z","timestamp":1464661531000},"page":"1650075","source":"Crossref","is-referenced-by-count":5,"title":["Generation Mechanism of Alternans in Luo\u2013Rudy Model"],"prefix":"10.1142","volume":"26","author":[{"given":"Hiroyuki","family":"Kitajima","sequence":"first","affiliation":[{"name":"Faculty of Engineering, Kagawa University, 2217-20 Hayashi, Takamatsu, Kagawa 761-0396, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Ioka","sequence":"additional","affiliation":[{"name":"College of Science and Engineering, Aoyama Gakuin University, 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Yazawa","sequence":"additional","affiliation":[{"name":"Faculty of Urban Liberal Arts, Tokyo Metropolitan University, Minami-Ohsawa, Hachioji, Tokyo 192-0397, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2016,5,30]]},"reference":[{"doi-asserted-by":"publisher","key":"S0218127416500759BIB001","DOI":"10.1063\/1.1499275"},{"doi-asserted-by":"publisher","key":"S0218127416500759BIB002","DOI":"10.1063\/1.2715668"},{"doi-asserted-by":"publisher","key":"S0218127416500759BIB003","DOI":"10.1103\/PhysRevLett.99.058101"},{"doi-asserted-by":"publisher","key":"S0218127416500759BIB004","DOI":"10.1161\/01.CIR.77.5.1125"},{"doi-asserted-by":"publisher","key":"S0218127416500759BIB005","DOI":"10.1016\/j.compchemeng.2007.10.019"},{"doi-asserted-by":"publisher","key":"S0218127416500759BIB006","DOI":"10.1063\/1.1501544"},{"key":"S0218127416500759BIB007","first-page":"208101","volume":"88","author":"Echebarria B.","year":"2002","journal-title":"Phys. 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