{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:02:12Z","timestamp":1649116932014},"reference-count":3,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Artif. Intell. Tools"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p> In bioinformatics, biochemical pathways can be modeled by many differential equations. It is still an open problem how to fit the huge amount of parameters of the equations to the available data. Here, the approach of systematically learning the parameters is necessary. <\/jats:p><jats:p> In this paper, for the small, important example of inflammation modeling a network is constructed and different learning algorithms are proposed. It turned out that due to the nonlinear dynamics evolutionary approaches are necessary to fit the parameters for sparse, given data. <\/jats:p>","DOI":"10.1142\/s0218213004001855","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T12:24:48Z","timestamp":1104236688000},"page":"851-862","source":"Crossref","is-referenced-by-count":0,"title":["ADAPTIVE MODELING OF BIOCHEMICAL PATHWAYS"],"prefix":"10.1142","volume":"13","author":[{"given":"R.","family":"BRAUSE","sequence":"first","affiliation":[{"name":"J. W. G. University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","unstructured":"R.\u00a0Brause, Sepsis, SIRS, Immune Response - Concepts, Diagnostics and Therapy, eds. A.\u00a0Nierhaus and J.\u00a0Schulte am Esch (PABST Science Publishers, Lengerich, Germany, 2003)\u00a0pp. 122\u2013129."},{"key":"rf4","volume-title":"Development of a Dynamical Systems Model of Acute Inflammation","author":"Chow C.","year":"2003"},{"key":"rf9","volume-title":"Evolution and Optimum Seeking","author":"Schwefel H.-P","year":"1995"}],"container-title":["International Journal on Artificial Intelligence Tools"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0218213004001855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T16:52:42Z","timestamp":1565196762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0218213004001855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":3,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2011,11,21]]},"published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1142\/S0218213004001855"],"URL":"https:\/\/doi.org\/10.1142\/s0218213004001855","relation":{},"ISSN":["0218-2130","1793-6349"],"issn-type":[{"value":"0218-2130","type":"print"},{"value":"1793-6349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}