{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:01:15Z","timestamp":1754398875900},"reference-count":47,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Artif. Intell. Tools"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p> Fuzzy association rules can reveal useful dependencies and interactions hidden in large gene expression data sets. However their derivation perplexes very difficult combinatorial problems that depend heavily on the size of these sets. The paper follows a divide and conquer approach to the problem that obtains computationally manageable solutions. Initially we cluster genes that more probably are associated. Thereafter, the fuzzy association rule extraction algorithms confront many but significantly reduced computationally problems that usually can be processed very fast. <\/jats:p><jats:p> The clustering phase is accomplished by means of an approach based on mutual information (MI). This approach uses the mutual information as a similarity measure. However, the numerical evaluation of the MI is subtle. We experiment with the main methods and we compare between them. As the device that implements the mutual information clustering we use a SOM (Self-Organized Map) based approach that is capable of effectively incorporating supervised bias. <\/jats:p><jats:p> After the mutual information clustering phase the fuzzy association rules are extracted locally on a per cluster basis. The paper presents an application of the techniques for mining the gene expression data. However, the presented techniques can easily be adapted and can be fruitful for intelligent exploration of any other similar data set as well. <\/jats:p>","DOI":"10.1142\/s0218213006002643","type":"journal-article","created":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T10:41:10Z","timestamp":1142937670000},"page":"227-250","source":"Crossref","is-referenced-by-count":4,"title":["MUTUAL INFORMATION CLUSTERING FOR EFFICIENT MINING OF FUZZY ASSOCIATION RULES WITH APPLICATION TO GENE EXPRESSION DATA ANALYSIS"],"prefix":"10.1142","volume":"15","author":[{"given":"STERGIOS","family":"PAPADIMITRIOU","sequence":"first","affiliation":[{"name":"Department of Information Management, Technological Educational Institute of Kavala, 65404 Kavala, Greece"}]},{"given":"SEFERINA","family":"MAVROUDI","sequence":"additional","affiliation":[{"name":"Pattern Recognition Laboratory, Department of Computer Engineering and Informatics, School of Engineering, University of Patras, Rion, Patras, 26500, Greece"}]},{"given":"SPIRIDON D.","family":"LIKOTHANASSIS","sequence":"additional","affiliation":[{"name":"Pattern Recognition Laboratory, Department of Computer Engineering and Informatics, School of Engineering, University of Patras, Rion, Patras, 26500, Greece"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.1.262"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14863"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.11.1446"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1109\/72.925554"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/17.2.126"},{"key":"rf7","first-page":"2907","volume":"92","author":"Tamayo P.","journal-title":"Proc. Natl. Acad. Sci., USA"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1089\/106652700750050961"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02332159"},{"key":"rf10","first-page":"1560","volume":"14","author":"Van Hulle M. M.","journal-title":"Neural Computation"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1162\/089976698300017179"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1109\/72.846731"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-6080(00)00039-3"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1007\/s005210170021"},{"key":"rf15","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-6080(01)00020-X"},{"key":"rf16","doi-asserted-by":"publisher","DOI":"10.1162\/089976602760128054"},{"key":"rf17","doi-asserted-by":"publisher","DOI":"10.1109\/10.914796"},{"key":"rf18","doi-asserted-by":"publisher","DOI":"10.1162\/089976601300014466"},{"key":"rf19","doi-asserted-by":"publisher","DOI":"10.1162\/089976602753284509"},{"key":"rf20","doi-asserted-by":"publisher","DOI":"10.1162\/089976600300014836"},{"key":"rf21","doi-asserted-by":"publisher","DOI":"10.1162\/089976698300017953"},{"key":"rf22","volume-title":"Data Mining","author":"Witten Ian H.","year":"2000"},{"key":"rf23","doi-asserted-by":"publisher","DOI":"10.1109\/72.846732"},{"key":"rf24","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-97966-8"},{"key":"rf25","volume-title":"Neural Networks","author":"Haykin S.","year":"1999"},{"key":"rf26","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1684(02)00469-3"},{"key":"rf27","volume-title":"Data Mining: Multimedia, Soft Computing, and Bioinformatics","author":"Mitra Sushmita","year":"2003"},{"key":"rf28","volume-title":"Learning with Kernels: Support Vector Machines, Regularization and Beyond","author":"Scholkopf Bernhard","year":"2002"},{"key":"rf29","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.79"},{"key":"rf31","author":"Scholkopf B.","journal-title":"Neural Computation"},{"key":"rf32","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0779(94)90020-5"},{"key":"rf33","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-2789(98)00269-3"},{"key":"rf34","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.52.2318"},{"key":"rf35","volume":"69","author":"Kraskov Alexander","journal-title":"Phys. Rev. E"},{"key":"rf36","volume":"70","author":"Stogbauer Harald","journal-title":"Phys. Rev. E"},{"key":"rf37","first-page":"1","volume":"1","author":"Daub Carsten O.","journal-title":"Bioinformatics"},{"key":"rf38","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-2789(00)00043-9"},{"key":"rf39","doi-asserted-by":"publisher","DOI":"10.1109\/TNN.2004.828766"},{"key":"rf40","first-page":"1191","volume":"6","author":"Paninski Lian","journal-title":"Neural Computation"},{"key":"rf41","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2005.29"},{"key":"rf42","doi-asserted-by":"publisher","DOI":"10.1109\/72.712161"},{"key":"rf44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1109\/TCBB.2005.17","volume":"2","author":"Au Wai-Ho","journal-title":"IEEE Transactions on Computational Biology and Bioinformatics"},{"key":"rf45","doi-asserted-by":"publisher","DOI":"10.1142\/S0219720004000612"},{"key":"rf46","doi-asserted-by":"publisher","DOI":"10.1142\/S0219720005000874"},{"key":"rf47","doi-asserted-by":"publisher","DOI":"10.1142\/S0219720003000071"},{"key":"rf48","doi-asserted-by":"publisher","DOI":"10.1142\/S021972000400048X"},{"key":"rf49","doi-asserted-by":"publisher","DOI":"10.1142\/S0219720005001491"},{"key":"rf50","first-page":"1107","volume":"3","author":"Goh L.","journal-title":"Computational Biology"}],"container-title":["International Journal on Artificial Intelligence Tools"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0218213006002643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T16:54:08Z","timestamp":1565196848000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0218213006002643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":47,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2011,11,21]]},"published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1142\/S0218213006002643"],"URL":"https:\/\/doi.org\/10.1142\/s0218213006002643","relation":{},"ISSN":["0218-2130","1793-6349"],"issn-type":[{"value":"0218-2130","type":"print"},{"value":"1793-6349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}