{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T15:14:34Z","timestamp":1769872474351,"version":"3.49.0"},"reference-count":41,"publisher":"World Scientific Pub Co Pte Ltd","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Image Grap."],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p> Alzheimer\u2019s Disease (AD) is basically a progressive neurodegenerative disorder associated with abnormal brain networks that affect millions of elderly people and degrades their quality of life. The abnormalities in brain networks are due to the disruption of White Matter (WM) fiber tracts that connect the brain regions. Diffusion-Weighted Imaging (DWI) captures the brain\u2019s WM integrity. Here, the correlation betwixt the WM degeneration and also AD is investigated by utilizing graph theory as well as Machine Learning (ML) algorithms. By using the DW image obtained from Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) database, the brain graph of each subject is constructed. The features extracted from the brain graph form the basis to differentiate between Mild Cognitive Impairment (MCI), Control Normal (CN) and AD subjects. Performance evaluation is done using binary and multiclass classification algorithms and obtained an accuracy that outperforms the current top-notch DWI-based studies. <\/jats:p>","DOI":"10.1142\/s021946782240006x","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T15:12:04Z","timestamp":1640272324000},"source":"Crossref","is-referenced-by-count":3,"title":["Graph Theory-Based Brain Network Connectivity Analysis and Classification of Alzheimer\u2019s Disease"],"prefix":"10.1142","volume":"23","author":[{"given":"A.","family":"Thushara","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, TKM College of Engineering, APJ Abdul Kalam Technological University, Kollam, Kerala 691005, India"}]},{"given":"C. Ushadevi","family":"Amma","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communications Engineering, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Vallikavu PO, Amritapuri, Clappana, Kerala 690525, India"}]},{"given":"Ansamma","family":"John","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, TKM College of Engineering, APJ Abdul Kalam Technological University, Kollam, Kerala 691005, India"}]}],"member":"219","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"issue":"3","key":"S021946782240006XBIB001","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.nurt.2007.05.011","volume":"4","author":"Alexander A. L.","year":"2007","journal-title":"Neurotherapeutics"},{"issue":"1","key":"S021946782240006XBIB002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1052-5149(03)00067-4","volume":"12","author":"Ito R.","year":"2002","journal-title":"Neuroimaging Clin. N. 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