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Short cycles reduce the length of detours when a connection is clipped, so we propose that long cycles in metabolism may have been selected against in order to shorten transition times and reduce the likelihood of oscillations in response to external perturbations.<\/jats:p>","DOI":"10.1142\/s0219525901000140","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:00:37Z","timestamp":1027767637000},"page":"207-226","source":"Crossref","is-referenced-by-count":61,"title":["RELEVANT CYCLES IN CHEMICAL REACTION NETWORKS"],"prefix":"10.1142","volume":"04","author":[{"given":"PETRA M.","family":"GLEISS","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Theoretische Chemie und Molekulare Strukturbiologie, Universit\u00e4t Wien, W\u00e4hringerstra\u00dfe 17, A-1090 Wien, Austria"}]},{"given":"PETER F.","family":"STADLER","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Theoretische Chemie und Molekulare Strukturbiologie, Universit\u00e4t Wien, W\u00e4hringerstra\u00dfe 17, A 1090 Wien, Austria"},{"name":"Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA"}]},{"given":"ANDREAS","family":"WAGNER","sequence":"additional","affiliation":[{"name":"Dept. of Biology, University of New Mexico, 167A Castetter Hall, Albuquerque, NM-817131-1091, USA"},{"name":"Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA"}]},{"given":"DAVID A.","family":"FELL","sequence":"additional","affiliation":[{"name":"School of Biological &amp; Molecular Sciences, Oxford Brookes University, Oxford OX3 OBP, UK"}]}],"member":"219","published-online":{"date-parts":[[2011,11,20]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.85.5234"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200327197"},{"key":"p_3","first-page":"1205","volume":"11","author":"Balaban A. 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