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In order to understand the origins of this topology and its evolutionary implications, we present a simple model of proteome evolution that is able to reproduce many of the observed statistical regularities reported from the analysis of the yeast proteome. Our results suggest that the observed patterns can be explained by a process of gene duplication and diversification that would evolve proteome networks under a selection pressure, favoring robustness against failure of its individual components. <\/jats:p>","DOI":"10.1142\/s021952590200047x","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T07:07:52Z","timestamp":1027753672000},"page":"43-54","source":"Crossref","is-referenced-by-count":234,"title":["A MODEL OF LARGE-SCALE PROTEOME EVOLUTION"],"prefix":"10.1142","volume":"05","author":[{"given":"RICARD V.","family":"SOL\u00c9","sequence":"first","affiliation":[{"name":"ICREA-Complex Systems Research Group, FEN, Universitat Polit\u00e8cnica de Catalunya, Campus Nord B4,     08034 Barcelona, Spain"},{"name":"Santa Fe Institute, 1399 Hyde Park Road,  New Mexico 87501, USA"},{"name":"NASA-associated Astrobiology Institute,  INTA\/CSIC, Carr. del Ajalvir Km4, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROMUALDO","family":"PASTOR-SATORRAS","sequence":"additional","affiliation":[{"name":"ICREA-Complex Systems Research Group, FEN, Universitat Polit\u00e8cnica de Catalunya, Campus Nord B4,     08034 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERIC","family":"SMITH","sequence":"additional","affiliation":[{"name":"Santa Fe Institute, 1399 Hyde Park Road,  New Mexico 87501, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS B.","family":"KEPLER","sequence":"additional","affiliation":[{"name":"Santa Fe Institute, 1399 Hyde Park Road,  New Mexico 87501, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2011,11,20]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1038\/35019019"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200327197"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(98)01312-2"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.509"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1038\/ng0196-72"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2000.1280"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1038\/81025"},{"key":"p_10","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1098\/rspb.2001.1800","volume":"268","author":"Ferrer","year":"2001","journal-title":"Procs. 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