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Nevertheless, there are some general principles that govern their overall behavior. We focus on the question to what extent the dynamics of replication can explain the accumulation of genetic information that eventually leads to the emergence of the first cell and hence the origin of life as we know it. A large class of ligation-based replication systems, which includes the experimentally available model systems for template directed self-replication, is of particular interest because its dynamics bridges the gap between the survival of a single fittest species to the global coexistence of everthing. In this intermediate regime the selection is weak enough to allow the coexistence of genetically unrelated replicators and strong enough to limit the accumulation of disfunctional mutants.<\/jats:p>","DOI":"10.1142\/s0219525903000724","type":"journal-article","created":{"date-parts":[[2003,6,25]],"date-time":"2003-06-25T09:45:35Z","timestamp":1056534335000},"page":"47-77","source":"Crossref","is-referenced-by-count":33,"title":["MOLECULAR REPLICATOR DYNAMICS"],"prefix":"10.1142","volume":"06","author":[{"given":"B\u00c4RBEL M. 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