{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T21:42:02Z","timestamp":1649108522150},"reference-count":34,"publisher":"World Scientific Pub Co Pte Lt","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advs. Complex Syst."],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p> We present statistical mechanics models to understand the physical and molecular mechanisms of X-Chromosome Inactivation (XCI), the process whereby a female mammal cell inactivates one of its two X-chromosomes. During XCI, X-chromosomes undergo a series of complex regulatory processes. At the beginning of XCI, the X's recognize and pair, then only one X which is randomly chosen is inactivated. Afterwards, the two X's move to different positions in the cell nucleus according to their different status (active\/silenced). Our models illustrate about the still mysterious physical bases underlying all these regulatory steps, i.e., X-chromosome pairing, random choice of inactive X, and \"shuttling\" of the X's to their post-XCI locations. Our models are based on general and robust thermodynamic roots, and their validity can go beyond XCI, to explain analogous regulatory mechanisms in a variety of cellular processes. <\/jats:p>","DOI":"10.1142\/s0219525910002566","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T07:00:35Z","timestamp":1278658835000},"page":"367-376","source":"Crossref","is-referenced-by-count":0,"title":["STATISTICAL MECHANICS MODELS FOR X-CHROMOSOME INACTIVATION"],"prefix":"10.1142","volume":"13","author":[{"given":"ANTONIO","family":"SCIALDONE","sequence":"first","affiliation":[{"name":"Department of Physics, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK"},{"name":"INFN, Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIO","family":"NICODEMI","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK"},{"name":"INFN, Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2011,11,20]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1149420"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1038\/35047580"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1016\/j.physa.2008.12.003"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/60\/5\/001"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024922626726"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152850"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1038\/nature08098"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.11.017"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1148910"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1038\/nature06947"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.4.3156"},{"key":"rf12","first-page":"45","volume":"9","author":"Kumar P. 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