{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:51:13Z","timestamp":1740167473889,"version":"3.37.3"},"reference-count":50,"publisher":"World Scientific Pub Co Pte Ltd","issue":"07n08","funder":[{"name":"Conacyt"},{"DOI":"10.13039\/501100006087","name":"Direcci\u00c3n General Asuntos del Personal Acad\u00c3\u00a9mico, Universidad Nacional Aut\u00c3noma de M\u00c3\u00a9xico (MX)","doi-asserted-by":"publisher","award":["IN120509"],"award-info":[{"award-number":["IN120509"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006087","name":"Direcci\u00c3n General Asuntos del Personal Acad\u00c3\u00a9mico, Universidad Nacional Aut\u00c3noma de M\u00c3\u00a9xico (MX)","doi-asserted-by":"publisher","award":["IN113414"],"award-info":[{"award-number":["IN113414"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advs. Complex Syst."],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Homologous recombination is an important operator in the evolution of biological organisms. However, there is still no clear, generally accepted understanding of why it exists and under what circumstances it is useful. In this paper, we consider its utility in the context of an infinite population haploid model with selection and homologous recombination. We define utility in terms of two metrics \u2014 the increase in frequency of fit genotypes, and the increase in average population fitness, relative to those associated with selection only. Explicitly, we explore the full parameter space of a two-locus two-allele system, showing, as a function of the landscape and the initial population, that recombination is beneficial in terms of these metrics in two distinct regimes: a relatively landscape independent regime \u2014 the search regime\u00a0\u2014 where recombination aids in the search for a fit genotype that is absent or at low frequency in the population; and the modular regime, where recombination allows for the juxtaposition of fit \u201cmodules\u201d or Building Blocks (BBs). Thus, we conclude that the ubiquity and utility of recombination is intimately associated with the existence of modularity and redundancy in biological fitness landscapes.<\/jats:p>","DOI":"10.1142\/s0219525915500265","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T15:16:26Z","timestamp":1455808586000},"page":"1550026","source":"Crossref","is-referenced-by-count":1,"title":["FITNESS LANDSCAPE EPISTASIS AND RECOMBINATION"],"prefix":"10.1142","volume":"18","author":[{"given":"MANUEL BELTR\u00c1N","family":"DEL R\u00cdO","sequence":"first","affiliation":[{"name":"Center for Diseases of the Pancreas, Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA"},{"name":"C3 \u2013 Centro de Ciencias de la Complejidad, Circuito Exterior, A. 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