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Through visualizing the system dynamics on a synthesized fitness landscape which results from the superposition of the phase diagram and the individual fitness landscape, we entertain a simple theoretical framework that not only helps analyze our simulated multicellular dynamics but is potentially applicable to a broader class of problems in CASs where relaxation and adaptation intertwine. It is stressed that the nonadaptive relaxation process has the essential role in shaping the selective pressure of adaptation as well as in defining the final state of the evolution, whereas it is the rigidity of mutation strategy that determines the complexity of the dynamical process.<\/jats:p>","DOI":"10.1142\/s0219525917500163","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T08:56:27Z","timestamp":1514451387000},"page":"1750016","source":"Crossref","is-referenced-by-count":1,"title":["WHEN RELAXATION MEETS ADAPTATION IN COMPLEX ADAPTIVE SYSTEMS: A COMPUTATIONAL STUDY OF TUMORIGENESIS"],"prefix":"10.1142","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1634-1673","authenticated-orcid":false,"given":"YUTING","family":"LOU","sequence":"first","affiliation":[{"name":"Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Chiba 277-8563, Japan"}]},{"given":"QI","family":"SHENG","sequence":"additional","affiliation":[{"name":"Department of Physics, Columbia University, New York, New York 10027, USA"}]},{"given":"YU","family":"CHEN","sequence":"additional","affiliation":[{"name":"Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Chiba 277-8563, Japan"}]}],"member":"219","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"S0219525917500163BIB001","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3915"},{"key":"S0219525917500163BIB002","doi-asserted-by":"publisher","DOI":"10.4324\/9781315072012"},{"key":"S0219525917500163BIB003","doi-asserted-by":"publisher","DOI":"10.1016\/j.plrev.2005.03.002"},{"key":"S0219525917500163BIB004","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.03.043"},{"key":"S0219525917500163BIB005","volume-title":"The Economy as an Evolving Complex System II","volume":"28","author":"Arthur W. 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