{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:33:28Z","timestamp":1709512408962},"reference-count":35,"publisher":"World Scientific Pub Co Pte Lt","issue":"07n08","funder":[{"name":"NSF PHY","award":["1205840","1545832"],"award-info":[{"award-number":["1205840","1545832"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advs. Complex Syst."],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p> Boolean models represent a drastic simplification of complex biomolecular systems, and yet accurately predict system properties, e.g., effective control strategies. Why is this? Parameter robustness has been highlighted as a general feature of biomolecular systems and may play an important role in the accuracy of Boolean models. We argue here that a useful way to view a system\u2019s controllability properties is through its repertoire of self-sustaining positive circuits (stable motifs). We examine attractor control and self-sustaining circuits within the cell cycle restriction switch, a bistable regulatory circuit that allows or prevents entry into the cell cycle. We explore this system using three models: a previously published Boolean model, a Hill kinetics model that we construct from the Boolean model using the HillCube methodology, and a reaction-based model we construct from the literature. We highlight the robustness of stable motifs across these three levels of modeling detail. We also show how consideration of control-robust regulatory circuits can aid in parameter specification. <\/jats:p>","DOI":"10.1142\/s0219525919500206","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T05:55:16Z","timestamp":1582696516000},"page":"1950020","source":"Crossref","is-referenced-by-count":5,"title":["CONTROLLING THE CELL CYCLE RESTRICTION SWITCH ACROSS THE INFORMATION GRADIENT"],"prefix":"10.1142","volume":"22","author":[{"given":"JORDAN C.","family":"ROZUM","sequence":"first","affiliation":[{"name":"Department of Physics, The Pennsylvania State University, 121 Davey Laboratory, University Park, PA 16803, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00c9KA","family":"ALBERT","sequence":"additional","affiliation":[{"name":"Departments of Physics and Biology, The Pennsylvania State University, 152E Davey Laboratory, University Park, PA 16803, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"S0219525919500206BIB001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2006.09.023"},{"key":"S0219525919500206BIB002","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(03)00035-3"},{"key":"S0219525919500206BIB003","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308265100"},{"key":"S0219525919500206BIB004","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.2003.817920"},{"key":"S0219525919500206BIB005","doi-asserted-by":"publisher","DOI":"10.1063\/1.5083060"},{"key":"S0219525919500206BIB006","doi-asserted-by":"publisher","DOI":"10.1016\/j.automatica.2009.03.006"},{"key":"S0219525919500206BIB007","doi-asserted-by":"publisher","DOI":"10.1242\/dev.112573"},{"key":"S0219525919500206BIB008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07473.x"},{"key":"S0219525919500206BIB009","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001672"},{"key":"S0219525919500206BIB010","doi-asserted-by":"publisher","DOI":"10.1038\/srep21957"},{"key":"S0219525919500206BIB011","doi-asserted-by":"publisher","DOI":"10.1007\/s10884-013-9312-7"},{"key":"S0219525919500206BIB012","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.97.042308"},{"key":"S0219525919500206BIB013","doi-asserted-by":"publisher","DOI":"10.1038\/35018085"},{"key":"S0219525919500206BIB014","doi-asserted-by":"publisher","DOI":"10.1007\/s11047-015-9520-7"},{"key":"S0219525919500206BIB015","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.119.268301"},{"key":"S0219525919500206BIB016","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-233"},{"key":"S0219525919500206BIB017","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.052"},{"key":"S0219525919500206BIB018","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100557"},{"key":"S0219525919500206BIB019","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2013.1"},{"key":"S0219525919500206BIB020","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318192110"},{"key":"S0219525919500206BIB021","doi-asserted-by":"publisher","DOI":"10.1038\/35106065"},{"key":"S0219525919500206BIB022","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2013.06.009"},{"key":"S0219525919500206BIB023","doi-asserted-by":"publisher","DOI":"10.1126\/science.2683075"},{"key":"S0219525919500206BIB024","doi-asserted-by":"publisher","DOI":"10.1016\/j.aam.2007.11.003"},{"key":"S0219525919500206BIB025","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006630"},{"key":"S0219525919500206BIB026","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2018.09.017"},{"key":"S0219525919500206BIB027","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183372"},{"key":"S0219525919500206BIB028","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006402"},{"key":"S0219525919500206BIB029","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8240(05)80199-5"},{"key":"S0219525919500206BIB030","doi-asserted-by":"publisher","DOI":"10.1002\/jez.10144"},{"key":"S0219525919500206BIB031","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-3-98"},{"key":"S0219525919500206BIB032","doi-asserted-by":"publisher","DOI":"10.1063\/1.4809777"},{"key":"S0219525919500206BIB033","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004193"},{"key":"S0219525919500206BIB034","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/aaffa1"},{"key":"S0219525919500206BIB035","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617387114"}],"container-title":["Advances in Complex Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0219525919500206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T09:22:11Z","timestamp":1585819331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0219525919500206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":35,"journal-issue":{"issue":"07n08","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1142\/S0219525919500206"],"URL":"https:\/\/doi.org\/10.1142\/s0219525919500206","relation":{},"ISSN":["0219-5259","1793-6802"],"issn-type":[{"value":"0219-5259","type":"print"},{"value":"1793-6802","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}