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This methodology has three main phases: (i) representation of scores as a decision tree; (ii) optimization of the decision tree thresholds using data from recent clinical datasets; (iii) transformation of the optimized decision tree into a new score. <\/jats:p><jats:p> This approach was validated in a cardiovascular disease secondary prevention context, supported by a dataset provided by the Portuguese Society of Cardiology ([Formula: see text]). The respective performance was assessed using statistical metrics and was compared with GRACE score, the reference in Portuguese clinical practice. 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