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The aim of the current study is to discuss a novel spatiotemporal tool for monitoring and predicting the phenomenon of the seasonal influenza epidemic spread in the human population using multiple regression analysis. The suggested tool is mainly based on three sub-systems. It allows generating simulation data by the use of a simulation system, integrating data sources in a data warehouse (DW) system and performing a specific online analysis Spatial On-Line Analytical Processing (SOLAP). Our proposal enables also to illustrate evolution of disease through visualizations in time and space. It can examine social network effects to better understand the topological structure of social contact and the impact of its properties. A regression analysis is performed on the influenza epidemic to examine the main factors influencing flu incidence number and therefore to predict and track influenza epidemic.<\/jats:p>","DOI":"10.1142\/s0219622019500408","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T08:24:42Z","timestamp":1570436682000},"page":"1755-1783","source":"Crossref","is-referenced-by-count":4,"title":["Integration of Multiple Regression Model in an Epidemiological Decision Support System"],"prefix":"10.1142","volume":"18","author":[{"given":"Fatima-Zohra","family":"Younsi","sequence":"first","affiliation":[{"name":"LIO Laboratory, University of Oran 1, Ahmed Ben Bella, BP 1524, El-M\u2019Naouer 31000, Oran, Algeria"}]},{"given":"Ahmed","family":"Bounnekar","sequence":"additional","affiliation":[{"name":"Polytechnic School, University of Claude Bernard Lyon 1, Lyon 69622, France"}]},{"given":"Djamila","family":"Hamdadou","sequence":"additional","affiliation":[{"name":"LIO Laboratory, University of Oran 1, Ahmed Ben Bella, BP 1524, El-M\u2019Naouer 31000, Oran, Algeria"}]},{"given":"Omar","family":"Boussaid","sequence":"additional","affiliation":[{"name":"ERIC Laboratory, University of Lumi\u00e8re Lyon 2, 5 Avenue Pierre Mend\u00e8s-France, 9676 Bron Cedex, France"}]}],"member":"219","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"S0219622019500408BIB002","doi-asserted-by":"publisher","DOI":"10.1038\/280455a0"},{"key":"S0219622019500408BIB003","volume-title":"Infectious Diseases of Humans: Dynamics and Control","volume":"28","author":"May R. 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