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Two unique peptide motifs were experimentally confirmed to contain epitopes for monoclonal antibodies (mAbs) specifically against RNase3. Further analysis of homologous RNases in different species revealed that the unique peptide motifs were located at the correspondent positions, and one of these motifs indeed matched the epitope for a specific anti-bovine pancreatic RNaseA (bpRNaseA) antibody. Our method provides a useful tool for identification of unique peptide motifs for further experimental design. The RMA system is available and free for academic use at and .<\/jats:p>","DOI":"10.1142\/s0219720006001710","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T00:43:38Z","timestamp":1143506618000},"page":"75-92","source":"Crossref","is-referenced-by-count":2,"title":["UNIQUE PEPTIDE IDENTIFICATION OF RNaseA SUPERFAMILY SEQUENCES BASED ON REINFORCED MERGING ALGORITHMS"],"prefix":"10.1142","volume":"04","author":[{"given":"TUN-WEN","family":"PAI","sequence":"first","affiliation":[{"name":"Department of Computer Science, National Taiwan Ocean University, No. 2, Pei-Ning Road, Keelung, Taiwan 20224, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BO-HAN","family":"SU","sequence":"additional","affiliation":[{"name":"Department of Computer Science, National Taiwan Ocean University, No. 2, Pei-Ning Road, Keelung, Taiwan 20224, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PEI-CHIH","family":"WU","sequence":"additional","affiliation":[{"name":"Department of Computer Science, National Taiwan Ocean University, No. 2, Pei-Ning Road, Keelung, Taiwan 20224, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARGARET DAH-TSYR","family":"CHANG","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Biology &amp; Department of Life Science, National Tsing Hua University, No. 101, Sec. 2, Kuang Fu Road, Hsinchu, Taiwan 30013, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HAO-TENG","family":"CHANG","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Biology &amp; Department of Life Science, National Tsing Hua University, No. 101, Sec. 2, Kuang Fu Road, Hsinchu, Taiwan 30013, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAN-CHI","family":"FAN","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Biology &amp; Department of Life Science, National Tsing Hua University, No. 101, Sec. 2, Kuang Fu Road, Hsinchu, Taiwan 30013, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHI-HWEI","family":"LIU","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Biology &amp; Department of Life Science, National Tsing Hua University, No. 101, Sec. 2, Kuang Fu Road, Hsinchu, Taiwan 30013, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(93)90166-X"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00508a035"},{"key":"rf3","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.4049\/jimmunol.137.9.2913","volume":"137","author":"Slifman N. 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