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To facilitate the system to overcome energy barriers, the Wang\u2013Landau method was employed, where a random walk is performed in the energy space with a uniform probability. Native-like structures were predicted at both levels for two model systems, each of which consists of two transmembrane helices. Interestingly, consistent results were obtained from simulations at the residue and atom levels for the same system, strongly suggesting the feasibility of a hierarchical approach for membrane protein structure predictions.<\/jats:p>","DOI":"10.1142\/s0219720006001965","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T03:00:12Z","timestamp":1152500412000},"page":"317-333","source":"Crossref","is-referenced-by-count":5,"title":["STRUCTURE PREDICTION OF HELICAL TRANSMEMBRANE PROTEINS AT TWO LENGTH SCALES"],"prefix":"10.1142","volume":"04","author":[{"given":"ZHONG","family":"CHEN","sequence":"first","affiliation":[{"name":"Dept. of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YING","family":"XU","sequence":"additional","affiliation":[{"name":"Dept. of Biochemistry and Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, GA 30602, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-1669(99)00056-7"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560070420"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0134(199611)26:3<257::AID-PROT2>3.0.CO;2-B"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1002\/prot.1151"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(02)75647-6"},{"key":"rf7","first-page":"50","volume":"6","author":"Pappu R. 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