{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:08:50Z","timestamp":1760645330063},"reference-count":33,"publisher":"World Scientific Pub Co Pte Lt","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Bioinform. Comput. Biol."],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Ovarian cancer recurs at the rate of 75% within a few months or several years later after therapy. Early recurrence, though responding better to treatment, is difficult to detect. Surface-enhanced laser desorption\/ionization time-of-flight (SELDI-TOF) mass spectrometry has showed the potential to accurately identify disease biomarkers to help early diagnosis. A major challenge in the interpretation of SELDI-TOF data is the high dimensionality of the feature space. To tackle this problem, we have developed a multi-step data processing method composed of t-test, binning and backward feature selection. A new algorithm, support vector machine-Markov blanket\/recursive feature elimination (SVM-MB\/RFE) is presented for the backward feature selection. This method is an integration of minimum weight feature elimination by SVM-RFE and information theory based redundant\/irrelevant feature removal by Markov Blanket. Subsequently, SVM was used for classification. We conducted the biomarker selection algorithm on 113 serum samples to identify early relapse from ovarian cancer patients after primary therapy. To validate the performance of the proposed algorithm, experiments were carried out in comparison with several other feature selection and classification algorithms.<\/jats:p>","DOI":"10.1142\/s0219720006002399","type":"journal-article","created":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T11:41:58Z","timestamp":1169552518000},"page":"1159-1179","source":"Crossref","is-referenced-by-count":18,"title":["PROTEOMIC BIOMARKER IDENTIFICATION FOR DIAGNOSIS OF EARLY RELAPSE IN OVARIAN CANCER"],"prefix":"10.1142","volume":"04","author":[{"given":"JUNG HUN","family":"OH","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, University of Texas, Arlington, TX 76019, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANIMESH","family":"NANDI","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Translational Pathology, University of Texas at Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PREM","family":"GURNANI","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Translational Pathology, University of Texas at Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LYNNE","family":"KNOWLES","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Gynaecologic Oncology, University of Texas at Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"SCHORGE","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Gynaecologic Oncology, University of Texas at Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KEVIN P.","family":"ROSENBLATT","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Translational Pathology, University of Texas at Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN X.","family":"GAO","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, University of Texas, Arlington, TX 76019, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.068"},{"key":"rf2","first-page":"926","volume":"96","author":"Knowles L. M.","journal-title":"Gynecol. Oncol."},{"key":"rf3","first-page":"2099","volume":"361","author":"Parmar M. K.","journal-title":"Lancet"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth446"},{"key":"rf5","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/clinchem\/48.8.1296","volume":"48","author":"Li J.","journal-title":"Clin. Chem."},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.55.091902.105237"},{"key":"rf7","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/clinchem\/47.10.1901","volume":"47","author":"Srinivas P. R.","journal-title":"Clin. Chem."},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1043"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07746-2"},{"key":"rf10","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/clinchem\/48.10.1835","volume":"48","author":"Qu Y.","journal-title":"Clin. Chem."},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1089\/106652703322756159"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200300523"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1155\/S1110724303210020"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2.6.549"},{"key":"rf15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth098"},{"key":"rf16","first-page":"3609","volume":"62","author":"Adam B. L.","journal-title":"Cancer Res."},{"key":"rf17","first-page":"308","volume":"5","author":"Vlahou A.","journal-title":"J. Biomed. Biotechnol."},{"key":"rf18","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.3.395"},{"key":"rf19","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg210"},{"key":"rf20","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.10.906"},{"key":"rf21","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.suppl_2.S75"},{"key":"rf22","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/17.suppl_1.S157"},{"key":"rf23","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012487302797"},{"key":"rf25","volume-title":"Probabilistic reasoning in intelligent Systems","author":"Pearl J.","year":"1988"},{"key":"rf27","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth947"},{"key":"rf28","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009715923555"},{"key":"rf29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2532248100"},{"key":"rf30","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/17.suppl_1.S306"},{"key":"rf32","volume-title":"Advances in Kernel Methods \u2014 Support Vector Learning","author":"Joachims T.","year":"1999"},{"key":"rf33","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"rf34","volume-title":"C4.5: Programs for Machine Learning","author":"Quinlan J. R.","year":"1993"},{"key":"rf35","volume-title":"Introduction to Statistical Pattern Recognition","author":"Fukunaga K.","year":"1990"},{"key":"rf36","volume-title":"Data Mining: Practical Machine Learning Tools and Techniques","author":"Witten I. H.","year":"2005"}],"container-title":["Journal of Bioinformatics and Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0219720006002399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T21:24:33Z","timestamp":1587331473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0219720006002399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":33,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2011,11,21]]},"published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1142\/S0219720006002399"],"URL":"https:\/\/doi.org\/10.1142\/s0219720006002399","relation":{},"ISSN":["0219-7200","1757-6334"],"issn-type":[{"value":"0219-7200","type":"print"},{"value":"1757-6334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}