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Because they incorporate structural and experimental data that is not used in sequence-based methods, they can provide additional accuracy and reliability to protein function prediction. Here, first we review the definition of protein function. Then the recent developments of these methods are introduced with special focus on the type of predictions that can be made. The need for further development of comprehensive systems biology techniques that can utilize the ever-increasing data presented by the genomics and proteomics communities is emphasized. For the readers' convenience, tables of useful online resources in each category are included. The role of computational scientists in the near future of biological research and the interplay between computational and experimental biology are also addressed. <\/jats:p>","DOI":"10.1142\/s0219720007002503","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T07:37:04Z","timestamp":1177918624000},"page":"1-30","source":"Crossref","is-referenced-by-count":86,"title":["FUNCTION PREDICTION OF UNCHARACTERIZED PROTEINS"],"prefix":"10.1142","volume":"05","author":[{"given":"TROY","family":"HAWKINS","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAISUKE","family":"KIHARA","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Department of Computer Science, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1038\/76443"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/15.5.391"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1038\/381364a0"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1038\/4462"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061034498"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1038\/nbt790"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200300640"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1002-991"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1038\/35015694"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh063"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1101\/gr.3866105"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1038\/nrg890"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2006.01.007"},{"key":"rf15","first-page":"137","volume":"44","author":"Do J. 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