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In order to provide an accurate systematic view for the stochastic nature of the calcium channels, MACACO is composed of an experiment generator, a central simulation engine and a post-processing script component. Due to the computational complexity of the problem and the dimensions of the parameter space, the MACACO simulation engine employs a grid-enabled task farm. Having been designed as a computational biology tool, MACACO heavily borrows from the way cell physiologists conduct and report their experimental work. <\/jats:p>","DOI":"10.1142\/s0219720007002679","type":"journal-article","created":{"date-parts":[[2007,8,10]],"date-time":"2007-08-10T00:32:00Z","timestamp":1186705920000},"page":"755-772","source":"Crossref","is-referenced-by-count":7,"title":["PARALLEL STOCHASTIC SIMULATION OF MACROSCOPIC CALCIUM CURRENTS"],"prefix":"10.1142","volume":"05","author":[{"given":"VIRGINIA","family":"GONZ\u00c1LEZ\u2013V\u00c9LEZ","sequence":"first","affiliation":[{"name":"\u00c1rea de Qu\u00edmica Aplicada, Universidad Aut\u00f3noma Metropolitana\u2013Azcapotzalco, 02200 M\u00e9xico D.F., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HORACIO","family":"GONZ\u00c1LEZ\u2013V\u00c9LEZ","sequence":"additional","affiliation":[{"name":"School of Informatics, University of Edinburgh, Edinburgh EH9 3JZ, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1109\/TPDS.2003.1195409"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1984.0068"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.143bx.x"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2005.01.001"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1038\/299156a0"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1002\/cpe.710"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90408-5"},{"key":"rf8","volume-title":"Algorithmic Skeletons: Structured Management of Parallel Computation","author":"Cole M.","year":"1989"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1977.0137"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1981.0003"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(03)74831-0"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-4655(01)00144-8"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1016\/j.parco.2006.07.002"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-4825(03)00071-4"},{"key":"rf16","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(02)75301-0"},{"key":"rf18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1952.sp004764"},{"key":"rf19","doi-asserted-by":"publisher","DOI":"10.1016\/j.parco.2004.07.013"},{"key":"rf20","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000019740.52306.92"},{"key":"rf21","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1996.sp003959"},{"key":"rf22","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.89.6.985"},{"key":"rf23","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-0097-3"},{"key":"rf24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.969"},{"key":"rf25","unstructured":"G. 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