{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T04:33:28Z","timestamp":1722746008762},"reference-count":10,"publisher":"World Scientific Pub Co Pte Lt","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Bioinform. Comput. Biol."],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p> To have a better understanding of the mechanisms of disease development, knowledge of mutations and the genes on which the mutations occur is of crucial importance. Information on disease-related mutations can be accessed through public databases or biomedical literature sources. However, information retrieval from such resources can be problematic because of two reasons: manually created databases are usually incomplete and not up to date, and reading through a vast amount of publicly available biomedical documents is very time-consuming. In this paper, we describe an automated system, MuGeX (Mutation Gene eXtractor), that automatically extracts mutation\u2013gene pairs from Medline abstracts for a disease query. Our system is tested on a corpus that consists of 231 Medline abstracts. While recall for mutation detection alone is 85.9%, precision is 95.9%. For extraction of mutation\u2013gene pairs, we focus on Alzheimer's disease. The recall for mutation\u2013gene pair identification is estimated at 91.3%, and precision is estimated at 88.9%. With automatic extraction techniques, MuGeX overcomes the problems of information retrieval from public resources and reduces the time required to access relevant information, while preserving the accuracy of retrieved information. <\/jats:p>","DOI":"10.1142\/s021972000700317x","type":"journal-article","created":{"date-parts":[[2007,12,31]],"date-time":"2007-12-31T05:56:01Z","timestamp":1199080561000},"page":"1261-1275","source":"Crossref","is-referenced-by-count":26,"title":["APPLICATION OF AUTOMATIC MUTATION\u2013GENE PAIR EXTRACTION TO DISEASES"],"prefix":"10.1142","volume":"05","author":[{"given":"MUGE","family":"ERDOGMUS","sequence":"first","affiliation":[{"name":"Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OSMAN UGUR","family":"SEZERMAN","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","first-page":"S6","volume":"6","author":"McDonald R.","journal-title":"Bioinformatics"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth904"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth060"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.suppl_1.S249"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh162"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg449"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030016"},{"key":"rf13","unstructured":"J. J.\u00a0Rocchio, The SMART Retrieval System \u2014 Experiments in Automatic Document Processing, ed. G.\u00a0Salton (Prentice-Hall, Upper Saddle River, NJ, 1971)\u00a0pp. 313\u2013323."},{"key":"rf16","doi-asserted-by":"publisher","DOI":"10.1108\/eb046814"},{"key":"rf17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm235"}],"container-title":["Journal of Bioinformatics and Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S021972000700317X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T17:00:49Z","timestamp":1565197249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S021972000700317X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":10,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2011,11,21]]},"published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1142\/S021972000700317X"],"URL":"https:\/\/doi.org\/10.1142\/s021972000700317x","relation":{},"ISSN":["0219-7200","1757-6334"],"issn-type":[{"value":"0219-7200","type":"print"},{"value":"1757-6334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}