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Proteins with multi-state kinetics, on average, are more compact (compactness is 1.49 \u00b1 0.02 for proteins within the size range of 101\u2013151 amino acid residues) than proteins with two-state kinetics (compactness is 1.59 \u00b1 0.03 for proteins within the same size range of 101\u2013151 amino acid residues). We have shown that compactness for homologous proteins can explain both the difference in folding rates and the difference in folding mechanisms. <\/jats:p>","DOI":"10.1142\/s0219720008003618","type":"journal-article","created":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T11:01:05Z","timestamp":1220353265000},"page":"667-680","source":"Crossref","is-referenced-by-count":24,"title":["COMPACTNESS DETERMINES PROTEIN FOLDING TYPE"],"prefix":"10.1142","volume":"06","author":[{"given":"OXANA V.","family":"GALZITSKAYA","sequence":"first","affiliation":[{"name":"Institute of Protein Research, Russian Academy of Sciences, Institutskaya Str. 4, Pushchino, Moscow Region 142290, Russia"}]},{"given":"NATALYA S.","family":"BOGATYREVA","sequence":"additional","affiliation":[{"name":"Institute of Protein Research, Russian Academy of Sciences, Institutskaya Str. 4, Pushchino, Moscow Region 142290, Russia"}]},{"given":"DMITRY N.","family":"IVANKOV","sequence":"additional","affiliation":[{"name":"Institute of Protein Research, Russian Academy of Sciences, Institutskaya Str. 4, Pushchino, Moscow Region 142290, Russia"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0278(97)00016-3"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0278(98)00033-9"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.1645"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0278(98)00021-2"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10343"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10518"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402659101"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1553"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1021\/bi972075u"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0398-229"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.2009"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0134(19980815)32:3<296::AID-PROT5>3.0.CO;2-G"},{"key":"rf13","first-page":"1457","volume":"5","author":"Thirumalai D.","journal-title":"J. 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