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We hypothesized that perhaps differences in interdomain hydrophobicity might play some role in this process. To test this hypothesis, we generated a heptadic model of the alpha helix and mapped the average hydrophobicities (coaxial) and hydrophobic moments (radial) of 108 TMDs found in 9 different human ST proteins. Our results, taken together with earlier work from other groups, suggest that spatial patterns of hydrophobicity found in TMDs 1 and 2 are consistent with a role for these domains in the initial anchoring of the nascent ST protein to the endoplasmic reticulum (ER), as it emerges from the ribosome complex and perhaps in the subsequent spatial organisation of STs.<\/jats:p>","DOI":"10.1142\/s0219720011005367","type":"journal-article","created":{"date-parts":[[2011,1,3]],"date-time":"2011-01-03T05:07:47Z","timestamp":1294031267000},"page":"471-488","source":"Crossref","is-referenced-by-count":1,"title":["PATTERNS OF HYDROPHOBICITY FOUND IN THE FIRST AND SECOND TRANSMEMBRANE DOMAINS OF SOLUTE TRANSPORTERS SUGGEST A POSSIBLE ROLE IN NASCENT PROTEIN ANCHORING AND ORGANIZATION"],"prefix":"10.1142","volume":"09","author":[{"given":"STEVE","family":"HODGKINSON","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy I, University Hospital Ulm, Weingartshofer Strasse 2, D-88214 Ravensburg, Germany"}]},{"given":"WOLFGANG P.","family":"KASCHKA","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy I, University Hospital Ulm, Weingartshofer Strasse 2, D-88214 Ravensburg, Germany"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020559"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj001"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1126\/science.3839598"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1192-y"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1002\/0471434043.ch8"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.059972"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.64.1.13-33.2000"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.64.2.354-411.2000"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087619"},{"key":"rf10","first-page":"752","volume":"431","author":"Yernool D.","journal-title":"Nature"},{"key":"rf11","first-page":"203","volume":"437","author":"Yamashita A.","journal-title":"Nature"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707688104"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1038\/nature05455"},{"key":"rf14","first-page":"781","volume":"321","author":"Faham S.","journal-title":"Science"},{"key":"rf15","doi-asserted-by":"publisher","DOI":"10.1107\/S0365110X53001964"},{"key":"rf16","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(75)90123-0"},{"key":"rf17","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1279"},{"key":"rf18","doi-asserted-by":"publisher","DOI":"10.1021\/bi00469a001"},{"key":"rf19","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(04)00061-4"},{"key":"rf20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502810200"},{"key":"rf21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05800.x"},{"key":"rf22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605718200"},{"key":"rf23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bb.15.060186.001541"},{"key":"rf24","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4157(98)00021-5"},{"key":"rf25","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1016\/S0021-9258(19)69526-8","volume":"256","author":"Huang K. 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