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However, these methods have limitations, and the classification accuracy of the selected genes is less accurate. In this paper, we propose a set of univariate filter-based methods using a between-class overlapping criterion. The proposed techniques have been compared with many other univariate filter-based methods using an acute leukemia dataset. The following properties have been examined: classification accuracy of the selected individual genes and the gene subsets; redundancy check among selected genes using ridge regression and LASSO methods; similarity and sensitivity analyses; functional analysis; and, stability analysis. A comprehensive experiment shows promising results for our proposed techniques. The univariate filter based methods using between-class overlapping criterion are accurate and robust, have biological significance, and are computationally efficient and easy to implement. Therefore, they are well suited for biological and clinical discoveries.<\/jats:p>","DOI":"10.1142\/s0219720012500102","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T02:49:57Z","timestamp":1334717397000},"page":"1250010","source":"Crossref","is-referenced-by-count":21,"title":["A BETWEEN-CLASS OVERLAPPING FILTER-BASED METHOD FOR TRANSCRIPTOME DATA ANALYSIS"],"prefix":"10.1142","volume":"10","author":[{"given":"ALOK","family":"SHARMA","sequence":"first","affiliation":[{"name":"Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan"},{"name":"School of Engineering and Physics, Faculty of Science Technology and Environment, University of the South Pacific, Suva, Fiji"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SEIYA","family":"IMOTO","sequence":"additional","affiliation":[{"name":"Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SATORU","family":"MIYANO","sequence":"additional","affiliation":[{"name":"Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,8]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1142\/S0218001488000145"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-3702(00)00052-7"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211566398"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012487302797"},{"key":"rf5","first-page":"1205","volume":"5","author":"Yu L.","journal-title":"J. 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