{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:31:47Z","timestamp":1781677907505,"version":"3.54.5"},"reference-count":24,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Bioinform. Comput. Biol."],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p> Metabolic models are the most widespread type of models in systems biology and are currently used in several applications, including metabolic engineering and investigations of pathological states in which metabolic disorders play a relevant role. Once a model has been defined and corroborated, sensitivity analysis techniques can be used to study the model behavior in relation to perturbations of the model parameters. Here, we describe how it is possible to combine regionalized sensitivity analysis and response surface methodology to screen and quantitatively characterize the relation between metabolic phenotypes and biochemical reactions rates. By means of this approach, we identified the most important reactions for the citric acid efflux from mitochondria, one of the key metabolic traits of cancer cells. <\/jats:p>","DOI":"10.1142\/s0219720013400027","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T09:43:46Z","timestamp":1359366226000},"page":"1340002","source":"Crossref","is-referenced-by-count":3,"title":["SENSITIVITY ANALYSIS FOR STUDYING THE RELATION BETWEEN BIOCHEMICAL REACTIONS AND METABOLIC PHENOTYPES"],"prefix":"10.1142","volume":"11","author":[{"given":"CARLO","family":"MAJ","sequence":"first","affiliation":[{"name":"Istituto Tecnologie Biomediche \u2013 Consiglio Nazionale Ricerche, Via F.lli Cervi 93, 20090 Segrate, Italy"},{"name":"Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 Degli Studi di Milano-Bicocca, Viale Sarca 336, Milano 20126, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ETTORE","family":"MOSCA","sequence":"additional","affiliation":[{"name":"Istituto Tecnologie Biomediche \u2013 Consiglio Nazionale Ricerche, Via F.lli Cervi 93, 20090 Segrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IVAN","family":"MERELLI","sequence":"additional","affiliation":[{"name":"Istituto Tecnologie Biomediche \u2013 Consiglio Nazionale Ricerche, Via F.lli Cervi 93, 20090 Segrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GIANCARLO","family":"MAURI","sequence":"additional","affiliation":[{"name":"Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 Degli Studi di Milano-Bicocca, Viale Sarca 336, Milano 20126, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUCIANO","family":"MILANESI","sequence":"additional","affiliation":[{"name":"Istituto Tecnologie Biomediche \u2013 Consiglio Nazionale Ricerche, Via F.lli Cervi 93, 20090 Segrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/9780262195485.001.0001"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.08.004"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2009.77"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq141"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.10.002"},{"key":"rf6","volume-title":"Front Matter, in Global Sensitivity Analysis. 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