{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:31:35Z","timestamp":1761129095372},"reference-count":22,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Bioinform. Comput. Biol."],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p> The GPCR genes have a variety of exon\u2013intron structures even though their proteins are all structurally homologous. We have examined all human GPCR genes with at least two functional protein isoforms, totaling 199, aiming to gain an understanding of what may have contributed to the large diversity of the exon\u2013intron structures of the GPCR genes. The 199 genes have a total of 808 known protein splicing isoforms with experimentally verified functions. Our analysis reveals that 1301 (80.6%) adjacent exon\u2013exon pairs out of the total of 1,613 in the 199 genes have either exactly one exon skipped or the intron in-between retained in at least one of the 808 protein splicing isoforms. This observation has a statistical significance p-value of 2.051762 * e<jats:sup>-09<\/jats:sup>, assuming that the observed splicing isoforms are independent of the exon\u2013intron structures. Our interpretation of this observation is that the exon boundaries of the GPCR genes are not randomly determined; instead they may be selected to facilitate specific alternative splicing for functional purposes. <\/jats:p>","DOI":"10.1142\/s0219720013500194","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T05:18:22Z","timestamp":1382678302000},"page":"1350019","source":"Crossref","is-referenced-by-count":4,"title":["FUNCTIONAL UNDERSTANDING OF THE DIVERSE EXON\u2013INTRON STRUCTURES OF HUMAN GPCR GENES"],"prefix":"10.1142","volume":"12","author":[{"given":"DOROTHY A.","family":"HAMMOND","sequence":"first","affiliation":[{"name":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA"}]},{"given":"VICTOR","family":"OLMAN","sequence":"additional","affiliation":[{"name":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA"}]},{"given":"YING","family":"XU","sequence":"additional","affiliation":[{"name":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA"},{"name":"College of Computer Science and Technology, Jilin University, P. R. China"}]}],"member":"219","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046221"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1124\/mi.7.1.5"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1101\/gr.9.12.1288"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki520"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1038\/ng0102-13"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090100"},{"key":"rf7","first-page":"931","volume":"431","author":"Collins F. 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