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However, a molecular mechanism of silencing with the participation of these promoter-rich regions remains obscure. It has been demonstrated that all islands interact with histone-like protein H-NS \u2014 a specific sentinel of foreign genes. In this study, we demonstrated the inhibitory effect of H-NS using \u0394hns mutant of Escherichia coli and showed that deletion of dps, encoding another protein of bacterial nucleoid, tended to decrease rather than increase the amount of island-specific transcripts. This observation precluded consideration of promoter islands as sites for targeted heterochromatization only and a computer search for the binding sites of 53 transcription factors (TFs) revealed six proteins, which may specifically regulate their transcriptional output.<\/jats:p>","DOI":"10.1142\/s0219720014410066","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T07:36:56Z","timestamp":1390462616000},"page":"1441006","source":"Crossref","is-referenced-by-count":24,"title":["<i>Promoter islands<\/i>as a platform for interaction with nucleoid proteins and transcription factors"],"prefix":"10.1142","volume":"12","author":[{"given":"Yuri A.","family":"Purtov","sequence":"first","affiliation":[{"name":"Department of Functional Genomics and Cellular Stress, Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Glazunova","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics and Cellular Stress, Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey S.","family":"Antipov","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics and Cellular Stress, Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia"},{"name":"Department of Biophysics and Biotechnology, Voronezh State University, Voronezh 394006, Russia"},{"name":"Research and Education Center, Pushchino State Institute of Natural Sciences, Pushchino, Moscow Region 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria O.","family":"Pokusaeva","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biotechnology, Voronezh State University, Voronezh 394006, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeny E.","family":"Fesenko","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics and Cellular Stress, Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Preobrazhenskaya","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biotechnology, Voronezh State University, Voronezh 394006, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin S.","family":"Shavkunov","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics and Cellular Stress, Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria N.","family":"Tutukina","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics and Cellular Stress, Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor I.","family":"Lukyanov","sequence":"additional","affiliation":[{"name":"Department of Radiation and Molecular Biology, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga N.","family":"Ozoline","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics and Cellular Stress, Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia"},{"name":"Research and Education Center, Pushchino State Institute of Natural Sciences, Pushchino, Moscow Region 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp490"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062601"},{"key":"rf3","first-page":"1128","volume":"28","author":"Shavkunov K. 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