{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:07:24Z","timestamp":1765609644147},"reference-count":40,"publisher":"World Scientific Pub Co Pte Lt","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Bioinform. Comput. Biol."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p> MicroRNAs (miRNAs) are small non-coding RNAs that have important functions in gene regulation. Since finding miRNA target experimentally is costly and needs spending much time, the use of machine learning methods is a growing research area for miRNA target prediction. In this paper, a new approach is proposed by using two popular ensemble strategies, i.e. Ensemble Pruning and Rotation Forest (EP-RTF), to predict human miRNA target. For EP, the approach utilizes Genetic Algorithm (GA). In other words, a subset of classifiers from the heterogeneous ensemble is first selected by GA. Next, the selected classifiers are trained based on the RTF method and then are combined using weighted majority voting. In addition to seeking a better subset of classifiers, the parameter of RTF is also optimized by GA. Findings of the present study confirm that the newly developed EP-RTF outperforms (in terms of classification accuracy, sensitivity, and specificity) the previously applied methods over four datasets in the field of human miRNA target. Diversity-error diagrams reveal that the proposed ensemble approach constructs individual classifiers which are more accurate and usually diverse than the other ensemble approaches. Given these experimental results, we highly recommend EP-RTF for improving the performance of miRNA target prediction. <\/jats:p>","DOI":"10.1142\/s0219720015500171","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T09:53:39Z","timestamp":1432806819000},"page":"1550017","source":"Crossref","is-referenced-by-count":13,"title":["A new approach to human microRNA target prediction using ensemble pruning and rotation forest"],"prefix":"10.1142","volume":"13","author":[{"given":"Reza","family":"Mousavi","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering, Graduate University of Advanced Technology, Kerman, Iran"}]},{"given":"Mahdi","family":"Eftekhari","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, Shahid Bahonar University of Kerman, Iran"}]},{"given":"Mehdi Ghezelbash","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Graduate University of Advanced Technology, Kerman, Iran"}]}],"member":"219","published-online":{"date-parts":[[2016,1,18]]},"reference":[{"key":"S0219720015500171BIB001","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.10.022"},{"key":"S0219720015500171BIB002","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2290"},{"key":"S0219720015500171BIB003","doi-asserted-by":"publisher","DOI":"10.2174\/138920209789208219"},{"key":"S0219720015500171BIB004","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030085"},{"key":"S0219720015500171BIB005","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1642"},{"key":"S0219720015500171BIB006","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-010-9194-0"},{"key":"S0219720015500171BIB007","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"S0219720015500171BIB008","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1379"},{"key":"S0219720015500171BIB009","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.01.025"},{"key":"S0219720015500171BIB010","doi-asserted-by":"publisher","DOI":"10.1002\/path.1825"},{"key":"S0219720015500171BIB011","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01018-3"},{"key":"S0219720015500171BIB012","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020363"},{"key":"S0219720015500171BIB013","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1184704"},{"key":"S0219720015500171BIB014","doi-asserted-by":"publisher","DOI":"10.1038\/ng2135"},{"key":"S0219720015500171BIB015","doi-asserted-by":"publisher","DOI":"10.1038\/ng1536"},{"key":"S0219720015500171BIB016","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2014.07.008"},{"key":"S0219720015500171BIB017","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070153"},{"key":"S0219720015500171BIB018","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.03.022"},{"key":"S0219720015500171BIB019","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9326-7"},{"key":"S0219720015500171BIB020","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022859003006"},{"key":"S0219720015500171BIB022","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2006.211"},{"key":"S0219720015500171BIB023","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-3702(02)00190-X"},{"key":"S0219720015500171BIB024","doi-asserted-by":"publisher","DOI":"10.1016\/j.inffus.2004.04.008"},{"key":"S0219720015500171BIB025","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2008.78"},{"key":"S0219720015500171BIB026","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2012.11.005"},{"key":"S0219720015500171BIB027","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024583"},{"key":"S0219720015500171BIB028","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-292"},{"key":"S0219720015500171BIB029","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-476"},{"key":"S0219720015500171BIB030","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm484"},{"key":"S0219720015500171BIB031","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq298"},{"key":"S0219720015500171BIB032","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj112"},{"key":"S0219720015500171BIB033","doi-asserted-by":"publisher","DOI":"10.1261\/rna.2239606"},{"key":"S0219720015500171BIB034","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1107"},{"key":"S0219720015500171BIB037","doi-asserted-by":"publisher","DOI":"10.1002\/0471660264"},{"key":"S0219720015500171BIB038","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn851"},{"key":"S0219720015500171BIB039","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp503"},{"key":"S0219720015500171BIB040","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-427"},{"key":"S0219720015500171BIB041","volume-title":"Pattern Recognition and Machine Learning","author":"Bishop CM","year":"2006"},{"key":"S0219720015500171BIB042","volume-title":"Pattern Classification","author":"Duda RO","year":"2012"},{"key":"S0219720015500171BIB044","first-page":"1","volume":"7","author":"Dem\u0161ar J","year":"2006","journal-title":"J Mach Learn Res"}],"container-title":["Journal of Bioinformatics and Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0219720015500171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T19:49:48Z","timestamp":1565120988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0219720015500171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":40,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2016,1,18]]},"published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1142\/S0219720015500171"],"URL":"https:\/\/doi.org\/10.1142\/s0219720015500171","relation":{},"ISSN":["0219-7200","1757-6334"],"issn-type":[{"value":"0219-7200","type":"print"},{"value":"1757-6334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}