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We explore the applicability of t-SNE to human genetic data and make these observations: (i) similar to previously used dimension reduction techniques such as principal component analysis (PCA), t-SNE is able to separate samples from different continents; (ii) unlike PCA, t-SNE is more robust with respect to the presence of outliers; (iii) t-SNE is able to display both continental and sub-continental patterns in a single plot. We conclude that the ability for t-SNE to reveal population stratification at different scales could be useful for human genetic association studies.<\/jats:p>","DOI":"10.1142\/s0219720017500172","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T03:23:34Z","timestamp":1498188214000},"page":"1750017","source":"Crossref","is-referenced-by-count":159,"title":["Application of t-SNE to human genetic data"],"prefix":"10.1142","volume":"15","author":[{"given":"Wentian","family":"Li","sequence":"first","affiliation":[{"name":"Robert S Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Cerise","sequence":"additional","affiliation":[{"name":"Robert S Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030, 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