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When the core genes in each genus were selected based on our statistical definition of \u201ccore genome\u201d, core genes were present in at least 92% of 52 Bifidobacterium and in 97% of 178 Lactobacillus genomes. Functional comparison of the core genes of the two genera revealed a significant difference in the categories \u201camino acid transport and metabolism\u201d representing their difference in niche specificity. Over-represented Bifidobacterium protein families were primarily involved in host interactions, the complex compound metabolism, and in stress responses. These findings coincide with the published information and validate our bias-resilient definition of the core genome. <\/jats:p>","DOI":"10.1142\/s0219720018400127","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T03:20:16Z","timestamp":1522120816000},"page":"1840012","source":"Crossref","is-referenced-by-count":12,"title":["Comparative analysis of probiotic bacteria based on a new definition of core genome"],"prefix":"10.1142","volume":"16","author":[{"given":"Maria","family":"Satti","sequence":"first","affiliation":[{"name":"Department of Genetics, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Yata 1111, Mishima, Shizuoka 411-8540, Japan"}]},{"given":"Yasuhiro","family":"Tanizawa","sequence":"additional","affiliation":[{"name":"Center for Information Biology, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411-8540, 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