{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:20:41Z","timestamp":1772558441616,"version":"3.50.1"},"reference-count":23,"publisher":"World Scientific Pub Co Pte Ltd","issue":"01","funder":[{"name":"Molecular and Cellular Biology Program","award":["01201353567"],"award-info":[{"award-number":["01201353567"]}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["18-14-00321"],"award-info":[{"award-number":["18-14-00321"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Bioinform. Comput. Biol."],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p> We have analyzed codon usage for poly-Q stretches of different lengths for the human proteome. First, we have obtained that all long poly-Q stretches in Protein Data Bank (PDB) belong to the disordered regions. Second, we have found the bias for codon usage for glutamine homo-repeats in the human proteome. In the cases when the same codon is used for poly-Q stretches only CAG triplets are found. Similar results are obtained for human proteins with glutamine homo-repeats associated with diseases. Moreover, for proteins associated with diseases (from the HraDis database), the fraction of proteins for which the same codon is used for glutamine homo-repeats is less (22%) than for proteins from the human proteome (26%). We have demonstrated for poly-Q stretches in the human proteome that in some cases (28) the splicing sites correspond to the homo-repeats and in 11 cases, these sites appear at the [Formula: see text]-terminal part of the homo-repeats with statistical significance 10[Formula: see text]. <\/jats:p>","DOI":"10.1142\/s0219720019500100","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T04:14:49Z","timestamp":1548389689000},"page":"1950010","source":"Crossref","is-referenced-by-count":3,"title":["Is there codon usage bias for poly-Q stretches in the human proteome?"],"prefix":"10.1142","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3962-1520","authenticated-orcid":false,"given":"Oxana V.","family":"Galzitskaya","sequence":"first","affiliation":[{"name":"Institute of Protein Research, Russian Academy of Sciences, Institutskaya Str., 4, Pushchino, Moscow Region 142290, Russia"}]},{"given":"Georgii S.","family":"Novikov","sequence":"additional","affiliation":[{"name":"St. Petersburg Academic University, Nanotechnology Research and Education Centre of the Russian Academy of Sciences, St. Petersburg, Khlopina Str., 8\/3, 194021, Russia"}]},{"given":"Nikita V.","family":"Dovidchenko","sequence":"additional","affiliation":[{"name":"Institute of Protein Research, Russian Academy of Sciences, Institutskaya Str., 4, Pushchino, Moscow Region 142290, Russia"}]},{"given":"Mikhail Yu.","family":"Lobanov","sequence":"additional","affiliation":[{"name":"Institute of Protein Research, Russian Academy of Sciences, Institutskaya Str., 4, Pushchino, Moscow Region 142290, Russia"}]}],"member":"219","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"S0219720019500100BIB001","doi-asserted-by":"publisher","DOI":"10.1021\/bi201155g"},{"key":"S0219720019500100BIB002","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00644"},{"key":"S0219720019500100BIB003","doi-asserted-by":"publisher","DOI":"10.2741\/3017"},{"key":"S0219720019500100BIB004","doi-asserted-by":"publisher","DOI":"10.1038\/srep26941"},{"key":"S0219720019500100BIB005","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22122027"},{"key":"S0219720019500100BIB006","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.6.1457"},{"key":"S0219720019500100BIB007","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701600200"},{"key":"S0219720019500100BIB008","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13722"},{"key":"S0219720019500100BIB009","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/208346"},{"key":"S0219720019500100BIB010","doi-asserted-by":"publisher","DOI":"10.1134\/S0026893312010128"},{"key":"S0219720019500100BIB011","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027142"},{"key":"S0219720019500100BIB012","doi-asserted-by":"publisher","DOI":"10.1039\/C5MB00273G"},{"key":"S0219720019500100BIB013","doi-asserted-by":"publisher","DOI":"10.1039\/C1MB05318C"},{"key":"S0219720019500100BIB014","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007517"},{"key":"S0219720019500100BIB015","doi-asserted-by":"publisher","DOI":"10.1101\/gr.3096505"},{"key":"S0219720019500100BIB016","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt927"},{"key":"S0219720019500100BIB017","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1157"},{"key":"S0219720019500100BIB018","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evy046"},{"key":"S0219720019500100BIB019","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-6-r59"},{"key":"S0219720019500100BIB020","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2012.01.001"},{"key":"S0219720019500100BIB021","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.276"},{"key":"S0219720019500100BIB022","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221891110"},{"key":"S0219720019500100BIB023","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01510-z"}],"container-title":["Journal of Bioinformatics and Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0219720019500100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T07:35:05Z","timestamp":1569310505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0219720019500100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":23,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,3,14]]},"published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1142\/S0219720019500100"],"URL":"https:\/\/doi.org\/10.1142\/s0219720019500100","relation":{},"ISSN":["0219-7200","1757-6334"],"issn-type":[{"value":"0219-7200","type":"print"},{"value":"1757-6334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}