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Given, for example, that gene expression levels measured at two adjacent time points in a time-series experiment are often similar to each other, we assume that each measurement in the time-series experiment will be less informative than each measurement in a steady-state experiment. Based on this idea, we propose a new inference method that relies heavily on informative gene expression data. Through numerical experiments, we prove that the quality of an inferred genetic network is slightly improved by heavily weighting informative gene expression data. In this study, we develop a new method by modifying the existing random-forest-based inference method to take advantage of its ability to analyze both time-series and static gene expression data. The idea we propose can be similarly applied to many of the other existing inference methods, as well. <\/jats:p>","DOI":"10.1142\/s021972001950015x","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T05:33:26Z","timestamp":1554874406000},"page":"1950015","source":"Crossref","is-referenced-by-count":11,"title":["Inference of genetic networks using random forests: Assigning different weights for gene expression data"],"prefix":"10.1142","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-2636","authenticated-orcid":false,"given":"Shuhei","family":"Kimura","sequence":"first","affiliation":[{"name":"Faculty of Engineering, Tottori University, 4-101, Koyama-minami, Tottori 680-8552, Japan"}]},{"given":"Masato","family":"Tokuhisa","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Tottori University, 4-101, Koyama-minami, Tottori 680-8552, Japan"}]},{"given":"Mariko","family":"Okada","sequence":"additional","affiliation":[{"name":"Institute for Protein Research, Osaka University, 3-2, Yamadaoka, Suita, Osaka 565-0871, Japan"}]}],"member":"219","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"S021972001950015XBIB002","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21715-0"},{"key":"S021972001950015XBIB003","doi-asserted-by":"publisher","DOI":"10.1109\/CIBCB.2017.8058522"},{"key":"S021972001950015XBIB004","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv268"},{"key":"S021972001950015XBIB005","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"S021972001950015XBIB006","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012776"},{"key":"S021972001950015XBIB007","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-39159-0_2"},{"key":"S021972001950015XBIB008","doi-asserted-by":"publisher","DOI":"10.1109\/BIBE.2018.00026"},{"key":"S021972001950015XBIB009","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4682-3-25"},{"key":"S021972001950015XBIB010","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti071"},{"key":"S021972001950015XBIB011","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083308"},{"key":"S021972001950015XBIB012","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth140"},{"key":"S021972001950015XBIB013","volume-title":"Numerical Recipes in C","author":"Press WH","year":"1995","edition":"2"},{"key":"S021972001950015XBIB014","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1979.10481038"},{"key":"S021972001950015XBIB015","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-8-305"},{"key":"S021972001950015XBIB016","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2011.11.008"},{"key":"S021972001950015XBIB017","doi-asserted-by":"publisher","DOI":"10.1142\/S0219720010004859"},{"key":"S021972001950015XBIB018","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00057"},{"key":"S021972001950015XBIB019","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003361"},{"key":"S021972001950015XBIB020","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt167"},{"key":"S021972001950015XBIB021","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913357107"},{"key":"S021972001950015XBIB022","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr373"},{"key":"S021972001950015XBIB023","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013397"},{"key":"S021972001950015XBIB024","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0361com"},{"key":"S021972001950015XBIB026","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1003"},{"key":"S021972001950015XBIB027","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.064915"}],"container-title":["Journal of Bioinformatics and Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S021972001950015X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T05:41:36Z","timestamp":1571204496000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S021972001950015X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":25,"journal-issue":{"issue":"04","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1142\/S021972001950015X"],"URL":"https:\/\/doi.org\/10.1142\/s021972001950015x","relation":{},"ISSN":["0219-7200","1757-6334"],"issn-type":[{"value":"0219-7200","type":"print"},{"value":"1757-6334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}