{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:19:52Z","timestamp":1753885192483,"version":"3.41.2"},"reference-count":19,"publisher":"World Scientific Pub Co Pte Ltd","issue":"01","funder":[{"DOI":"10.13039\/100007219","name":"natural science foundation of shanghai","doi-asserted-by":"publisher","award":["15zr1420800"],"award-info":[{"award-number":["15zr1420800"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Bioinform. Comput. Biol."],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p> HCoV-HKU1 is a [Formula: see text]-coronavirus with low pathogenicity, which usually leads to respiratory diseases. At present, a controversial issue is that whether the receptor binding site (RBS) of HCoV-HKU1 is located in the N-terminal domain (NTD) or the C-terminal domain (CTD) in the HCoV-HKU1 S protein. To address this issue, we used molecular docking technology to dock the NTD and CTD with 9-oxoacetylated sialic acid (9-O-Ac-Sia), respectively, with the results showing that the RBS of HCoV-HKU1 is located in the NTD (amino acid residues 80\u201395, 25\u201332). Our findings clarified the structural basis and molecular mechanism of the HCoV-HKU1 infection, providing important information for the development of therapeutic antibody drugs and the design of vaccines. <\/jats:p>","DOI":"10.1142\/s0219720021500347","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T03:26:41Z","timestamp":1635391601000},"source":"Crossref","is-referenced-by-count":0,"title":["Clarifying real receptor binding site between coronavirus HCoV-HKU1 and 9-O-Ac-Sia based on molecular docking"],"prefix":"10.1142","volume":"20","author":[{"given":"Xiaoyu","family":"Liu","sequence":"first","affiliation":[{"name":"National Pathogen Collection Center for Aquatic Animals, Ministry of Agriculture of China, Shanghai 201306, P.\u00a0R.\u00a0China"},{"name":"Department of Developmental Biology, College of Fisheries and Life Science, Shanghai Ocean University Shanghai 201306, P.\u00a0R.\u00a0China"}]},{"given":"Jingying","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Physical Education & Health Care, East China Normal University, Shanghai 200241, P.\u00a0R.\u00a0China"},{"name":"Department of Developmental Biology, College of Fisheries and Life Science, Shanghai Ocean University Shanghai 201306, P.\u00a0R.\u00a0China"}]},{"given":"Sicong","family":"Li","sequence":"additional","affiliation":[{"name":"National Pathogen Collection Center for Aquatic Animals, Ministry of Agriculture of China, Shanghai 201306, P.\u00a0R.\u00a0China"},{"name":"Department of Developmental Biology, College of Fisheries and Life Science, Shanghai Ocean University Shanghai 201306, P.\u00a0R.\u00a0China"}]},{"given":"Cai","family":"Wei","sequence":"additional","affiliation":[{"name":"National Pathogen Collection Center for Aquatic Animals, Ministry of Agriculture of China, Shanghai 201306, P.\u00a0R.\u00a0China"},{"name":"Department of Developmental Biology, College of Fisheries and Life Science, Shanghai Ocean University Shanghai 201306, P.\u00a0R.\u00a0China"}]},{"given":"Shihang","family":"Wang","sequence":"additional","affiliation":[{"name":"National Pathogen Collection Center for Aquatic Animals, Ministry of Agriculture of China, Shanghai 201306, P.\u00a0R.\u00a0China"},{"name":"Department of Developmental Biology, College of Fisheries and Life Science, Shanghai Ocean University Shanghai 201306, P.\u00a0R.\u00a0China"}]},{"given":"Xuanyu","family":"Xu","sequence":"additional","affiliation":[{"name":"National Pathogen Collection Center for Aquatic Animals, Ministry of Agriculture of China, Shanghai 201306, P.\u00a0R.\u00a0China"},{"name":"Department of Developmental Biology, College of Fisheries and Life Science, Shanghai Ocean University Shanghai 201306, P.\u00a0R.\u00a0China"}]},{"given":"Yin","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Pathogen Collection Center for Aquatic Animals, Ministry of 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