{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:11:21Z","timestamp":1764688281038},"reference-count":13,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Comp. Intel. Appl."],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p> This paper investigates the efficacy and reliability of Artificial Neural Networks (ANNs) as an intelligent decision support tool for pharmaceutical product formulation. Two case studies have been employed to evaluate capabilities of the Multilayer Perceptron network in predicting drug dissolution\/release profiles. Performances of the network were evaluated using similarity factor (f<jats:sub>2<\/jats:sub>) \u2014 an index recommended by the United States Food and Drug Administration for profile comparison in pharmaceutical research. In addition, the bootstrap method was applied to assess the network prediction reliability by estimating confidence intervals associated with the results. The Multilayer Perceptron network also demonstrated a superior performance in comparison with multiple regression models. The results reveal that the ANN system has potentials to be a decision support tool for profile prediction in pharmaceutical experimentation, and the bootstrap method could be used as a means to assess reliability of the network prediction. <\/jats:p>","DOI":"10.1142\/s1469026801000214","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:05:45Z","timestamp":1027767945000},"page":"187-202","source":"Crossref","is-referenced-by-count":10,"title":["PREDICTION OF DRUG DISSOLUTION PROFILES USING ARTIFICIAL NEURAL NETWORKS"],"prefix":"10.1142","volume":"01","author":[{"given":"SIOW SAN","family":"QUEK","sequence":"first","affiliation":[{"name":"School of Electrical and Electronic Engineering, University Science of Malaysia, Malaysia"}]},{"given":"CHEE PENG","family":"LIM","sequence":"additional","affiliation":[{"name":"School of Electrical and Electronic Engineering, University Science of Malaysia, Malaysia"}]},{"given":"KOK KHIANG","family":"PEH","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences,  University Science of Malaysia, Malaysia"}]}],"member":"219","published-online":{"date-parts":[[2012,1,25]]},"reference":[{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1016\/0893-6080(90)90004-5"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015843527138"},{"key":"p_5","first-page":"4","volume":"1","author":"Nestorov I.","year":"1999","journal-title":"APPS Pharmasci."},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016260720218"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(97)00030-8"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(97)00260-3"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1006\/jcis.1995.1117"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018857108713"},{"key":"p_11","first-page":"318","author":"Rumelhart D. E.","year":"1986","journal-title":"MA"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.3109\/03639049509069244"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011976615750"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1007\/BF02551274"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1016\/0098-1354(92)80035-8"}],"container-title":["International Journal of Computational Intelligence and Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S1469026801000214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T22:33:54Z","timestamp":1565130834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S1469026801000214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":13,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2012,1,25]]},"published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1142\/S1469026801000214"],"URL":"https:\/\/doi.org\/10.1142\/s1469026801000214","relation":{},"ISSN":["1469-0268","1757-5885"],"issn-type":[{"value":"1469-0268","type":"print"},{"value":"1757-5885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}