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In the second part of the paper, a microscopic approach, which focuses on the cellular scale, is presented. A hybrid model using agent-based modeling for the cell behavior and a PDE for the description of the tumor environment is presented. A sensitivity analysis is performed on the hybrid model for a better understanding of its impact on the tumor growth. Numerical experiments are provided for the proposed approaches. <\/jats:p>","DOI":"10.1142\/s1793962322500271","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T15:33:43Z","timestamp":1638545623000},"source":"Crossref","is-referenced-by-count":0,"title":["Simulating tumor growth using mathematical and agent-based modeling"],"prefix":"10.1142","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-2783","authenticated-orcid":false,"given":"Salma","family":"Chabbar","sequence":"first","affiliation":[{"name":"Mohammadia School of Engineering, LERMA, Avenue Ibn Sina B.P 765, Agdal, Rabat, 10090, Morocco"},{"name":"University of C\u00f4te d\u2019Azur, Nice, France"}]},{"given":"Aboulaich","family":"Rajae","sequence":"additional","affiliation":[{"name":"Mohammadia School of Engineering, LERMA, Avenue Ibn Sina B.P 765, Agdal, Rabat, 10090, Morocco"}]},{"given":"Habbal","family":"Abderrahmane","sequence":"additional","affiliation":[{"name":"University of C\u00f4te d\u2019Azur, Inria, LJAD, Parc Valrose 06108 Nice, France"},{"name":"Polytechnic Mohammed VI University, Ben Guerir, Morocco"}]},{"given":"El Guarmah","family":"El Mahdi","sequence":"additional","affiliation":[{"name":"Ecole Royale de l\u2019Air de Marrakech, Base des Ecoles des FAR Era, Marrakech, 40160, Morocco"}]}],"member":"219","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"S1793962322500271BIB002","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0996-62"},{"key":"S1793962322500271BIB004","doi-asserted-by":"publisher","DOI":"10.1137\/S0036144504446291"},{"key":"S1793962322500271BIB005","doi-asserted-by":"publisher","DOI":"10.1002\/mma.212"},{"key":"S1793962322500271BIB006","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.8.061505.095807"},{"key":"S1793962322500271BIB007","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7177(96)00053-2"},{"key":"S1793962322500271BIB008","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8240(03)00027-2"},{"key":"S1793962322500271BIB009","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2008.03.027"},{"key":"S1793962322500271BIB010","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149422"},{"key":"S1793962322500271BIB011","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2010.02.036"},{"key":"S1793962322500271BIB012","doi-asserted-by":"publisher","DOI":"10.1007\/s00285-008-0216-9"},{"key":"S1793962322500271BIB013","first-page":"65","volume":"3","author":"Folkman J.","year":"1992","journal-title":"Sem. 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