{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:06:03Z","timestamp":1791252363566,"version":"4.1.0"},"reference-count":36,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>The root of Arctium lappa Linne (A. lappa) (Compositae), a perennial herb, has been cultivated for a long time as a popular vegetable. In order to investigate the hepatoprotective effects of A. lappa, male ICR mice were injected with carbon tetrachloride ( CCl<jats:sub>4<\/jats:sub>, 32 \u03bcl\/kg, i.p.) or acetaminophen (600 mg\/kg. i.p.). A. lappa suppressed the SGOT and SGPT elevations induced by CCl<jats:sub>4<\/jats:sub>or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological observations. In an attempt to elucidate the possible mechanism(s) of this hepatoprotective effect, glutathione (GSH), cytochrome P-450 (P-450) and malondialdehyde (MDA) contents were studied. A. lappa reversed the decrease in GSH and P-450 induced by CCl<jats:sub>4<\/jats:sub>and acetaminophen. It was also found that A. lappa decreased the malondialdehyde (MDA) content in CCl<jats:sub>4<\/jats:sub>or acetaminophen-intoxicated mice. From these results, it was suggested that A. lappa could protect the liver cells from CCl<jats:sub>4<\/jats:sub>or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl<jats:sub>4<\/jats:sub>or acetaminophen.<\/jats:p>","DOI":"10.1142\/s0192415x00000210","type":"journal-article","created":{"date-parts":[[2003,11,5]],"date-time":"2003-11-05T14:31:33Z","timestamp":1068042693000},"page":"163-173","source":"Crossref","is-referenced-by-count":69,"title":["Hepatoprotective Effects of<i>Arctium Lappa<\/i>on Carbon Tetrachloride- and Acetaminophen-Induced Liver Damage"],"prefix":"10.1142","volume":"28","author":[{"given":"Song-chow","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Taipei Medical College, 250, Wu-hsing Street, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsao-chuen","family":"Chung","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Taipei Medical College, Taipei, Taiwan"},{"name":"Graduate Institute of Medical Technology, College of Medicine, National Taiwan University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-ching","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzuu-Huei","family":"Ueng","sequence":"additional","affiliation":[{"name":"Institutes of Toxicology, College of Medicine, National Taiwan University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-ho","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Taipei Medical College, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuw-yuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Hung-Kuang Institute of Technology, Taichung Hsien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-ya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Taipei Medical College, 250, Wu-hsing Street, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"p_1","first-page":"306","volume":"28","author":"Albano E.","year":"1985","journal-title":"Mol. 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