{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:48:41Z","timestamp":1760078921656},"reference-count":14,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p> Dai-Kenchu-To (DKT) is a herbal medicine and is currently used as the treatment of paralytic ileus in Japan. We investigated the mechanism of beneficial effects of DKT in vitro. DKT-extract powder (DKT-EP; 30\u2013300 \u03bcg\/ml) caused a significant inhibition on carbachol (CCH; 10<jats:sup>-6<\/jats:sup>)-induced contraction in a concentration dependent manner of the rat distal colon. DKT-EP (100 \u03bcg\/ml) consists of 20 \u03bcg\/ml of Zanthoxylum Fruit, 30 \u03bcg\/ml of Ginseng Root and 50 \u03bcg\/ml of Ginger Rhizome. Although each of them had no effect on CCH-induced muscle contraction, the combination of three ingredients caused a significant inhibition on CCH-induced contraction. <\/jats:p>","DOI":"10.1142\/s0192415x01000125","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T09:41:09Z","timestamp":1067334069000},"page":"111-118","source":"Crossref","is-referenced-by-count":12,"title":["The Inhibitory Effect of Herbal Medicine -Dai Kenchu To (DKT)- on the Colonic Motility in Rats <i>In Vitro<\/i>"],"prefix":"10.1142","volume":"29","author":[{"given":"Mohammad Alhakam","family":"Tulimat","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Ishiguchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Kurosawa","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Teikyo University, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Teikyo University, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toku","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2823384"},{"key":"p_2","first-page":"513","volume":"31","author":"Bielkiewicz-Vollrath B.","year":"1987","journal-title":"Mol. 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