{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:54:51Z","timestamp":1792007691232,"version":"4.4.0"},"reference-count":19,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>This study investigated the effects of acupuncture on carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) induced acute liver injury in male rats (n = 36). The experimental groups were injected with CCl<jats:sub>4<\/jats:sub>before, during, or after acupuncture therapy. Acupoints similar to the human Tsu-San-Li (St-36) and Tai-Chung (Li-3) were needled bilaterally. Rats treated with CCl<jats:sub>4<\/jats:sub>had higher levels of serum glutamate-oxalate-transaminase (sGOT) and serum glutamate-pyruvate-transaminase (sGPT). Comparing the experimental groups, biochemical and pathological parameters of liver injury were significantly reduced when rats were acupunctured after, not before, CCl<jats:sub>4<\/jats:sub>-induced hepatotoxicity. Acupuncture at the Tsu-Sa-Li and Tai-Chung acupoints cannot prevent acute liver injury but may be effective in treating liver injury induced by carbon tetrachloride in rats.<\/jats:p>","DOI":"10.1142\/s0192415x01000253","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T09:41:09Z","timestamp":1067334069000},"page":"221-226","source":"Crossref","is-referenced-by-count":15,"title":["The Effectiveness of Tsu-San-Li (St-36) and Tai-Chung (Li-3) Acupoints for Treatment of Acute Liver Damage in Rats"],"prefix":"10.1142","volume":"29","author":[{"given":"Hsu-Jan","family":"Liu","sequence":"first","affiliation":[{"name":"Acupuncture Research Center, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Feng","family":"Hsu","sequence":"additional","affiliation":[{"name":"Acupuncture Research Center, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Chi","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Institute of Chinese Pharmaceutical Science, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin-Yun","family":"Ho","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medical Science, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Liang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Chang Geng Traditional Chinese Medical Hospital and Chang Geng University, Graduate Institute of Traditional Chinese Medicine, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Post Baccalaureate Chinese Medicine, China Medical College, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaung-Geng","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medical Science, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.26.2316"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051146"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(05)80120-2"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-969416"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6429.1475"},{"key":"p_6","first-page":"185","volume":"109","author":"Lin J.G","year":"1996","journal-title":"Chin. 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