{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:36:52Z","timestamp":1770968212430,"version":"3.50.1"},"reference-count":20,"publisher":"World Scientific Pub Co Pte Ltd","issue":"02n03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>In this study, we investigated the effects of Inula Britannica on the production of antibodies against ovalbumin, and the differentiation of T cells, in C57BL\/6 mice. The oral administration of Inula Britannica suppressed IL-4 and IL-6 production in lymphocytes collected from an inguinal lymph node in the immunized leg. On the other hand, the intraperitoneal administration of Inula Britannica suppressed IgG1 production, the ratio of IFN-\u03b3<jats:sup>+<\/jats:sup>IL-4<jats:sup>-<\/jats:sup>\/IFN- \u03b3<jats:sup>-<\/jats:sup>IL-4<jats:sup>+<\/jats:sup>cells and cytokine production of IL-6. It was presumed that the effects of Inula Britannica on the production of antibodies were induced by regulation of the balance of Th1 and Th2. Further, IL-4 and IL-6 production by lymphocytes collected from an inguinal lymph node in the immunized leg were suppressed, and therefore production of antibodies was suppressed.<\/jats:p>","DOI":"10.1142\/s0192415x02000211","type":"journal-article","created":{"date-parts":[[2002,9,12]],"date-time":"2002-09-12T10:32:25Z","timestamp":1031826745000},"page":"297-305","source":"Crossref","is-referenced-by-count":15,"title":["Effects of<i>Inula Britannica<\/i>on the Production of Antibodies and Cytokines and on T Cell Differentiation in C57BL\/6 Mice Immunized by Ovalbumin"],"prefix":"10.1142","volume":"30","author":[{"given":"Qing-Hua","family":"Song","sequence":"first","affiliation":[{"name":"Department of Bioregulatory Function, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Bioregulatory Function, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tie","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Bioregulatory Function, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Chol","family":"Cyong","sequence":"additional","affiliation":[{"name":"Department of Bioregulatory Function, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,30]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820139809070900"},{"key":"p_2","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.4049\/jimmunol.147.11.3679","volume":"147","author":"Croft M.","year":"1991","journal-title":"J. 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