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Neurite outgrowth induced by NGF in PC12 cells is accompanied by sustained activation of mitogen-activated protein kinase (MAPK); however, these Chinese medicines did not induce MAPK activity. The findings thus indicate that certain Chinese medicines may induce neurite outgrowth by a novel mechanism which is distinct from the NGF-activated pathway in PC12 mutant cells. <\/jats:p>","DOI":"10.1142\/s0192415x02000260","type":"journal-article","created":{"date-parts":[[2002,9,12]],"date-time":"2002-09-12T06:32:25Z","timestamp":1031812345000},"page":"287-295","source":"Crossref","is-referenced-by-count":9,"title":["Chinese Medicine Induces Neurite Outgrowth in PC12 Mutant Cells Incapable of Differentiation"],"prefix":"10.1142","volume":"30","author":[{"given":"Yoshio","family":"Kano","sequence":"first","affiliation":[{"name":"Department of Health Science, Kibi International  University, 8 Iga-machi Takahashi-city,  Okayama 716-8508, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Takaguchi","sequence":"additional","affiliation":[{"name":"Department of Health Science, Kibi International  University, 8 Iga-machi Takahashi-city,  Okayama 716-8508, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Nohno","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Kawasaki Medical  School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukumi","family":"Hiragami","sequence":"additional","affiliation":[{"name":"Department of Health Science, Kibi International  University, 8 Iga-machi Takahashi-city,  Okayama 716-8508, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Health Science, Kibi International  University, 8 Iga-machi Takahashi-city,  Okayama 716-8508, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Iwama","sequence":"additional","affiliation":[{"name":"Department of Health Science, Kibi International  University, 8 Iga-machi Takahashi-city,  Okayama 716-8508, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Biology, Okayama University School of  Industrial Technology, 311 Tsushima-naka, Okayama City,  Okayama 700-0082, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Takehara","sequence":"additional","affiliation":[{"name":"Department of Nutrition Management, Faculty of Health  Science, Hyogo University, 2301 Hiraoka-machi, Shinzaike, Kakogawa-city,  Hyogo 675-0101, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,30]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000040200"},{"key":"p_2","first-page":"219","volume":"7","author":"Cornford E.M","year":"1985","journal-title":"Mol. 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